Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate
Date
1986
Authors
Du Toit D.F.
Heydenrych J.J.
Smit B.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The object of this prliminary study was to evaluate the endocrine function after heterotopic intraperitoneal segmental pancreatic allotransplantation with unligated duct in irradiated, totally pancreatectomized primates. All allograft recipients received, pre- and peroperative donor-specific blood transfusions and peroperative external irradiation from a linear accelerator; 200 rads was administered weekly and increased to a total dose of 1,5000 rads. Pancreatic transplantation was performed between 2 and 6 weeks after completion of irradiation and preoperative blood transfusions. As previously reported, only minimal pancreatic allograft survival was achieved following preoperative irradiation. One recipient remained normoglycaemic for > 100 days after transplantation, the longest surviving pancreatic allograft recipient reported from this laboratory. Intravenous glucose tolerance test results in this recipient revealed normoglycaemia, reduced K-value, hypoinsulinaemia, normal glucagon response, reduced C-peptide values, and moderate glucose intolerance. Aortography and electron-microscopic examination of allograft biopsy tissue confirmed the presence of a functioning allograft.
Description
Keywords
animal experiment, ape, endocrine system, endocrinology, glucose tolerance, immunosuppressive treatment, insulin release, irradiation, nonhuman, pancreas transplantation, priority journal, therapy, Animal, Female, Immunity, Immunosuppression, Lymphoid Tissue, Male, Pancreas, Pancreas Transplantation, Pancreatic Function Tests, Papio, Particle Accelerators, Support, Non-U.S. Gov't, Transplantation Immunology, Whole-Body Irradiation
Citation
Journal of Surgical Oncology
32
1
32
1