The extent of progressive familial heart block type 1 - A new perspective
Date
1994
Authors
Van Der Merwe P.-L.
Weymar H.W.
Kalis N.N.
Journal Title
Journal ISSN
Volume Title
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Abstract
New data on the inheritance of progressive familial heart block type I (PFHB1) does not favour the theory that the original immigrant (founder of PFHB1 families) introduced the genetic abnormality into South Africa and suggests that a new mutation in family member b6 was possibly responsible for the origin of the disease. If the mutation occurred in family member b6, this would reduce the number of affected family members from a previously estimated 9000 to a mere 860 with a revised prevalence of 1:5000 South Africans of European descent.
Description
Keywords
article, autosomal dominant inheritance, familial disease, heart block, human, major clinical study
Citation
Cardiovascular Journal of Southern Africa
5
3
5
3