Oral health and pathology: a macrophage account
Date
2012-01Author
Merry, R
Belfield, Louise
McArdle, P
McLennan, A
Crean, S
Foey, Andrew
Subject
Oral pathology Immunology Macrophages
Metadata
Show full item recordAbstract
Macrophages are present in healthy oral mucosa and their numbers increase dramatically during disease. They can exhibit a diverse range of phenotypes characterised as a functional spectrum from pro-inflammatory to anti-inflammatory (regulatory) subsets. This review illustrates the role of these subsets in the oral inflammatory disease lichen planus, and the immunosuppressive disease oral squamous cell carcinoma (SCC). We conclude that the role of macrophages in driving progression in oral disease identifies them as potential therapeutic targets for a range of oral pathologies.
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Publisher
Elsevier BV
Place of Publication
Scotland
Journal
British Journal of Oral and Maxillofacial Surgery
Volume
50
Issue
1
Pagination
2-7
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