Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses.
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Authors
Ederveen, Thomas H AFerwerda, Gerben
Ahout, Inge M
Vissers, Marloes
de Groot, Ronald
Boekhorst, Jos
Timmerman, Harro M
Huynen, Martijn A
van Hijum, Sacha A F T
de Jonge, Marien I
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ArticleLanguage
en
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Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses.Published in
Microbiome 2018; 6(1):10Publiekssamenvatting
While almost all infants are infected with respiratory syncytial virus (RSV) before the age of 2 years, only a small percentage develops severe disease. Previous studies suggest that the nasopharyngeal microbiome affects disease development. We therefore studied the effect of the nasopharyngeal microbiome on viral load and mucosal cytokine responses, two important factors influencing the pathophysiology of RSV disease. To determine the relation between (i) the microbiome of the upper respiratory tract, (ii) viral load, and (iii) host mucosal inflammation during an RSV infection, nasopharyngeal microbiota profiles of RSV infected infants (< 6 months) with different levels of disease severity and age-matched healthy controls were determined by 16S rRNA marker gene sequencing. The viral load was measured using qPCR. Nasopharyngeal CCL5, CXCL10, MMP9, IL6, and CXCL8 levels were determined with ELISA.PMID
29325581ae974a485f413a2113503eed53cd6c53
10.1186/s40168-017-0395-y
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