A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis.

Thomas, Binny; Mohamed, Mahmoud; Al Hail, Moza; Awwad, Fatma Alzahra Y.; Wahba, Ramy M.; Hassan, Sabir B.; Omar, Khalid; El Kassem, Wessam; Abdul Rouf, Pallivalapila

doi:10.2147/CPAA.S106234

A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis.

Thomas, Binny; Mohamed, Mahmoud; Al Hail, Moza; Awwad, Fatma Alzahra Y.; Wahba, Ramy M.; Hassan, Sabir B.; Omar, Khalid; El Kassem, Wessam; Abdul Rouf, Pallivalapila

Authors

Binny Thomas

Mahmoud Mohamed

Moza Al Hail

Fatma Alzahra Y. Awwad

Ramy M. Wahba

Sabir B. Hassan

Khalid Omar

Wessam El Kassem

Pallivalapila Abdul Rouf

Abstract

We report a case of 22-year-old primigravida presented to Women's Hospital - Hamad Medical Corporation emergency with severe epigastric pain, nausea, and vomiting. On admission, she was dehydrated with remarkably worsening symptoms. Laboratory findings revealed significantly elevated liver enzymes with unknown etiology. Her past medical history showed an admission for nausea and vomiting 3 weeks previously and she was discharged on antiemetics, and esomeprazole for the first time. Due to the predominantly elevated liver enzymes, the clinical pharmacist discussed the possibility of esomeprazole-induced adverse effects and suggested to suspend esomeprazole based on the evidence from literature review. The liver enzymes showed a substantial improvement within days after the discontinuation of the drug; however, a rechallenge was not done since it could have adversely affected the mother or the fetus. Using the Naranjo Adverse Drug Reaction Probability scales, the adverse reaction due to esomeprazole was classified as 'probably'.

Citation

THOMAS, B., MOHAMED, M., AL HAIL, M., AWWAD, F.A.Y., WAHBA, R.M., HASSAN, S.B., OMAR, K., EL KASSEM, W. and ABDUL ROUF, P. 2016. A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis. Clinical pharmacology: advances and applications [online], 8, pages 199-202. Available from: https://doi.org/10.2147/CPAA.S106234

Journal Article Type	Article
Acceptance Date	Aug 11, 2016
Online Publication Date	Dec 13, 2016
Publication Date	Dec 31, 2016
Deposit Date	Feb 2, 2017
Publicly Available Date	Feb 2, 2017
Journal	Clinical pharmacology: advances and applications
Print ISSN	1179-1438
Electronic ISSN	1179-1438
Publisher	Dove Medical Press
Peer Reviewed	Peer Reviewed
Volume	8
Pages	199-202
DOI	https://doi.org/10.2147/CPAA.S106234
Keywords	Hyperemesis; Drug induced liver injury; Esomeprazole; Adverse drug reaction; ADR; Proton pump inhibitor
Public URL	http://hdl.handle.net/10059/2147