WEKO3
アイテム
{"_buckets": {"deposit": "17ba0e19-747a-4915-90ee-fac415e56e10"}, "_deposit": {"created_by": 4, "id": "9204", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "9204"}, "status": "published"}, "_oai": {"id": "oai:naist.repo.nii.ac.jp:00009204", "sets": ["44"]}, "author_link": ["24344", "24345", "24346", "24347"], "item_7_biblio_info_9": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-05-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicVolumeNumber": "97", "bibliographic_titles": [{"bibliographic_title": "Physical Review E", "bibliographic_titleLang": "en"}]}]}, "item_7_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Living cells sense the mechanical properties of their surrounding environment and respond accordingly. Crawling cells detect the rigidity of their substratum and migrate in certain directions. They can be classified into two categories: slow-moving and fast-moving cell types. Slow-moving cell types, such as fibroblasts, smooth muscle cells, mesenchymal stem cells, etc., move toward rigid areas on the substratum in response to a rigidity gradient. However, there is not much information on rigidity sensing in fast-moving cell types whose size is ?10 μm and migration velocity is ?10 μm/min. In this study, we used both isotropic substrata with different rigidities and an anisotropic substratum that is rigid on the x axis but soft on the y axis to demonstrate rigidity sensing by fast-moving Dictyostelium cells and neutrophil-like differentiated HL-60 cells. Dictyostelium cells exerted larger traction forces on a more rigid isotropic substratum. Dictyostelium cells and HL-60 cells migrated in the “soft” direction on the anisotropic substratum, although myosin II?null Dictyostelium cells migrated in random directions, indicating that rigidity sensing of fast-moving cell types differs from that of slow types and is induced by a myosin II?related process.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_7_publisher_10": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "American Physical Society", "subitem_publisher_language": "en"}]}, "item_7_relation_15": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "29906928", "subitem_relation_type_select": "PMID"}}]}, "item_7_relation_17": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1103/PhysRevE.97.052401", "subitem_relation_type_select": "DOI"}}]}, "item_7_rights_18": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c2018 American Physical Society.", "subitem_rights_language": "en"}]}, "item_7_text_25": {"attribute_name": "NAIST ID", "attribute_value_mlt": [{"subitem_text_value": "73297863"}]}, "item_7_text_26": {"attribute_name": "artnum", "attribute_value_mlt": [{"subitem_text_value": "052401"}]}, "item_7_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Okimura, Chika", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24344", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakumura, Yuichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24345", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimabukuro, Katsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24346", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwadate, Yoshiaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "24347", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-03-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "10.1103_PhysRevE.97.052401.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "fulltext", "objectType": "fulltext", "url": "https://naist.repo.nii.ac.jp/record/9204/files/10.1103_PhysRevE.97.052401.pdf"}, "version_id": "fa567e45-9b18-42e5-a5f6-83b4462851ef"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Sensing of substratum rigidity and directional migration by fast-crawling cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Sensing of substratum rigidity and directional migration by fast-crawling cells", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "4", "path": ["44"], "permalink_uri": "http://hdl.handle.net/10061/12594", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-10-10"}, "publish_date": "2018-10-10", "publish_status": "0", "recid": "9204", "relation": {}, "relation_version_is_last": true, "title": ["Sensing of substratum rigidity and directional migration by fast-crawling cells"], "weko_shared_id": -1}
Sensing of substratum rigidity and directional migration by fast-crawling cells
http://hdl.handle.net/10061/12594
http://hdl.handle.net/10061/12594acfa3ba3-6927-4dcf-aaf4-2fbaae84776e
名前 / ファイル | ライセンス | アクション |
---|---|---|
fulltext (1.7 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-10-10 | |||||
タイトル | ||||||
タイトル | Sensing of substratum rigidity and directional migration by fast-crawling cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Okimura, Chika
× Okimura, Chika× Sakumura, Yuichi× Shimabukuro, Katsuya× Iwadate, Yoshiaki |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Living cells sense the mechanical properties of their surrounding environment and respond accordingly. Crawling cells detect the rigidity of their substratum and migrate in certain directions. They can be classified into two categories: slow-moving and fast-moving cell types. Slow-moving cell types, such as fibroblasts, smooth muscle cells, mesenchymal stem cells, etc., move toward rigid areas on the substratum in response to a rigidity gradient. However, there is not much information on rigidity sensing in fast-moving cell types whose size is ?10 μm and migration velocity is ?10 μm/min. In this study, we used both isotropic substrata with different rigidities and an anisotropic substratum that is rigid on the x axis but soft on the y axis to demonstrate rigidity sensing by fast-moving Dictyostelium cells and neutrophil-like differentiated HL-60 cells. Dictyostelium cells exerted larger traction forces on a more rigid isotropic substratum. Dictyostelium cells and HL-60 cells migrated in the “soft” direction on the anisotropic substratum, although myosin II?null Dictyostelium cells migrated in random directions, indicating that rigidity sensing of fast-moving cell types differs from that of slow types and is induced by a myosin II?related process. | |||||
書誌情報 |
en : Physical Review E 巻 97, 号 5, 発行日 2018-05-03 |
|||||
artnum | ||||||
052401 | ||||||
出版者 | ||||||
出版者 | American Physical Society | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 29906928 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1103/PhysRevE.97.052401 | |||||
権利 | ||||||
権利情報 | c2018 American Physical Society. | |||||
著者版フラグ | ||||||
出版タイプ | VoR |