The Effects of Social Housing and Running Exercise on Adult Hippocampal Neurogenesis and Pain Behaviors Alteration in Mice
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2009
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Haverford College. Department of Psychology
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eng
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Haverford users only
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Abstract
We investigated the effect of housing, physical exercise, or sex-related differences to adult CD-1 mice hippocampal neurogenesis development. 10 days exposure to social housing and physical exercise have been known to promote hippocampal neurogenesis. Sex-related differences in hippocampal neurogensis are investigated. We found no supporting evidences that social housing, access to running wheel, or female gender promoted hippocampal neurogenesis. We conducted two studies to analyze alterations in pain behaviors due to hippocampal neurogenesis. Study 1 examined the Stress Induced Analgesia response resulted from short period of restraint stressors by employing tail withdrawal test and hot plate test. We report that hot plate test is effective in measuring SIA response. A trend of female mice having stronger SIA response is observed. Group differences in hot plate test are dependent on the interactions between sex x running and in sex x housing. Female group housed mice, male individually housed mice, female non-runners, and male runners experienced more SIA response than their respective counterparts. Study 2 examined central sensitization event by employing the formalin test. Formalin injection to hind paw produces enhanced late phase pain behavior from early phase pain behavior. We report that access to running wheel, but not sex or social housing, significantly enhances late phase pain behavior. Group differences in formalin pain behavior are significantly dependent to housing. Access to running wheels only enhances late phase pain behaviors but not early phase pain behaviors.