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Nicaraven mitigates radiation-induced lung injury by downregulating the NF-κB and TGF-β/Smad pathways to suppress the inflammatory response
http://hdl.handle.net/10069/0002000377
http://hdl.handle.net/10069/000200037788bc7f30-53fd-441e-8614-d0d77ead4f12
名前 / ファイル | ライセンス | アクション |
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ISYK1557_XU.pdf (931 KB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2023-11-10 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Nicaraven mitigates radiation-induced lung injury by downregulating the NF-κB and TGF-β/Smad pathways to suppress the inflammatory response | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | radiation | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | DNA damage | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | lung injury | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | inflammatory response | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 |
徐, 勇
× 徐, 勇
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著者別名 | ||||||||
姓名 | XU, YONG | |||||||
言語 | en | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Radiation-induced lung injury (RILI) is commonly observed in patients receiving radiotherapy, and clinical prevention and treatment remain difficult. We investigated the effect and mechanism of nicaraven for mitigating RILI. C57BL/6 N mice (12-week-old) were treated daily with 6 Gy X-ray thoracic radiation for 5 days in sequences (cumulative dose of 30 Gy), and nicaraven (50 mg/kg) or placebo was injected intraperitoneally in 10 min after each radiation exposure. Mice were sacrificed and lung tissues were collected for experimental assessments at the next day (acute phase) or 100 days (chronic phase) after the last radiation exposure. Of the acute phase, immunohistochemical analysis of lung tissues showed that radiation significantly induced DNA damage of the lung cells, increased the number of Sca-1+ stem cells, and induced the recruitment of CD11c+, F4/80+ and CD206+ inflammatory cells. However, all these changes in the irradiated lungs were effectively mitigated by nicaraven administration. Western blot analysis showed that nicaraven administration effectively attenuated the radiation-induced upregulation of NF-κB, TGF-β, and pSmad2 in lungs. Of the chronic phase, nicaraven administration effectively attenuated the radiation-induced enhancement of α-SMA expression and collagen deposition in lungs. In conclusion we find that nicaraven can effectively mitigate RILI by downregulating NF-κB and TGF-β/pSmad2 pathways to suppress the inflammatory response in the irradiated lungs. | |||||||
言語 | en | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1557号 学位授与年月日:令和5年9月20日 | |||||||
言語 | ja | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Author: Yong Xu, Da Zhai, Shinji Goto, Xu Zhang, Keiichi Jingu and Tao-Sheng Li | |||||||
言語 | en | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Citation: Journal of Radiation Research, 63(2), pp. 158-165; 2022 | |||||||
言語 | en | |||||||
書誌情報 |
en : Journal of Radiation Research 巻 63, 号 2, p. 158-165, 発行日 2023-09-20 |
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ISSN | ||||||||
収録物識別子タイプ | EISSN | |||||||
収録物識別子 | 1349-9157 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.1093/jrr/rrab112 | |||||||
権利 | ||||||||
言語 | en | |||||||
権利情報 | © The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
その他のタイトル | ||||||||
その他のタイトル | Nicaravenは、NF-κB および TGF-β/Smad 経路を介して炎症反応の抑制により放射線肺損傷を軽減する | |||||||
言語 | ja | |||||||
出版者 | ||||||||
言語 | en | |||||||
出版者 | Oxford University Press | |||||||
関係URI | ||||||||
識別子タイプ | HDL | |||||||
関連識別子 | http://hdl.handle.net/10069/0002000228 | |||||||
学位名 | ||||||||
言語 | ja | |||||||
学位名 | 博士(医学) | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 17301 | |||||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2023-09-20 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲医歯薬第1557号 | |||||||
学位の種類 | ||||||||
ja | ||||||||
課程博士 | ||||||||
引用 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2023-09-20) |