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Expression and localisation of Rab44 in immune-related cells change during cell differentiation and stimulation
http://hdl.handle.net/10069/00040482
http://hdl.handle.net/10069/0004048299188d22-adf4-40ba-aeb5-caf89ed946d4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK1291_Tokuhisa.pdf (2.6 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2021-01-26 | |||||||
| タイトル | ||||||||
| タイトル | Expression and localisation of Rab44 in immune-related cells change during cell differentiation and stimulation | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
徳久, 美都子
× 徳久, 美都子
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| 著者別名 | ||||||||
| 識別子Scheme | WEKO | |||||||
| 識別子 | 112353 | |||||||
| 姓名 | Tokuhisa, Mitsuko | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Rab44 is a large Rab GTPase that contains a Rab-GTPase domain and some additional domains, such as EF-hand and coiled-coil domains at the N-terminus. Our previous study showed that Rab44 negatively regulates osteoclast differentiation by modulating intracellular calcium levels; however, aside from those findings, there is little information concerning Rab44 on other cells or tissues. In this study, we showed that Rab44 was highly expressed in bone marrow cells among various mouse tissues. Immunohistochemical studies indicated that Rab44 was detectable by only a small number of cells in the immune-related tissues and that Rab44 was partially detected in CD117-positive cells, but not in Stem cell antigen 1-positive cells in the bone marrow. Rab44 expression levels were decreased during differentiation of immune-related cells, such as neutrophils, macrophages, and dendritic cells compared with bone marrow cells. Although endogenous Rab44 in macrophages was localised in lysosomes, lipopolysaccharide (LPS) stimulation led to partial translocation to early endosomes and the plasma membrane. Moreover, Rab44 expression levels were altered by treatment with various immunomodulators, including LPS. These results indicate that Rab44 expression and localisation in bone marrow cells and macrophages alters with cell differentiation and stimulation. | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1291号 学位授与年月日:令和2年12月2日 | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Author: Mitsuko Tokuhisa, Tomoko Kadowaki, Kohei Ogawa, Yu Yamaguchi, Mizuho A. Kido, Weiqi Gao, Masahiro Umeda & Takayuki Tsukuba | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: Scientific Reports, 10, 10728; 2020 | |||||||
| 書誌情報 |
Scientific Reports 巻 10, p. 10728, 発行日 2020 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 20452322 | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1038/s41598-020-67638-7 | |||||||
| 権利 | ||||||||
| 権利情報 | © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 免疫関連細胞におけるRab44の発現分布は細胞の分化と刺激によって変化する | |||||||
| 出版者 | ||||||||
| 出版者 | Springer Nature | |||||||
| 関係URI | ||||||||
| 識別子タイプ | HDL | |||||||
| 関連識別子 | http://hdl.handle.net/10069/40435 | |||||||
| 学位名 | ||||||||
| 学位名 | 博士(歯学) | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 17301 | |||||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2020-12-02 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲医歯薬第1291号 | |||||||
| 学位の種類 | ||||||||
| 値 | 課程博士 | |||||||
| 引用 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Nagasaki University (長崎大学), 博士(歯学) (2020-12-02) | |||||||
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Cite as
徳久, 美都子, 2020, Expression and localisation of Rab44 in immune-related cells change during cell differentiation and stimulation: Springer Nature, 10728– p.
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