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Atherosclerosis as a Proliferative Disease of Arterial Intimal Cells : An ultrastructural, immunohistochemical, and in situ hybridization study
http://hdl.handle.net/10069/15796
http://hdl.handle.net/10069/1579680ec2f92-387d-4cf6-b4d3-a214e1a4a96c
名前 / ファイル | ライセンス | アクション |
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acta34_02_44_t.pdf (2.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Atherosclerosis as a Proliferative Disease of Arterial Intimal Cells : An ultrastructural, immunohistochemical, and in situ hybridization study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Toda, Takayoshi
× Toda, Takayoshi× Nagamine, Masaru× Saeki, Norihisa× Takei, Hiroshi× Hokama, Seitetsu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Coronary arterise obtained from 35 autopsied cases were studied with the aid of electron microscopy, immunohistochemistry, and in situ hybridization. Smooth muscle cells were the main cellular components of the fibrocellular intimal thickening of the coronary artery. Atherosclerotic lesions were characterized by proliferation of smooth muscle cells as well as foam cells. Ultrastructural and immunohistochemical studies indicated that, foam cells originated from smooth muscle cells and macrophages. Immunohistochemistry showed low levels of expression of the myc oncogene product in the lesions of fibrocellular intimal thickening and increased expression of that in the early stage of the athlrosclerotic lesions. Both smooth muscle cell and macrophage were responsible for the expression of the myc oncogene. In situ hybridization demonstrated the presence of m-RNA of myc oncogene in the intimal cells of the uncomplicated atherosclerotic lesions. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 34, 号 2-4, p. 250-256, 発行日 1989-12-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00250-P00256 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1989, 34(2-4), p.250-256 |