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In Vivo and in Vitro Activation of Lymphocytes by IFN-α and IFN-γ in Patients with Renal Cell Carcinoma
http://hdl.handle.net/10069/15968
http://hdl.handle.net/10069/159686f1137b5-4a32-4407-8f9d-bcd70c0958bb
名前 / ファイル | ライセンス | アクション |
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acta39_01_07_t.pdf (541.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | In Vivo and in Vitro Activation of Lymphocytes by IFN-α and IFN-γ in Patients with Renal Cell Carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Sakaguchi, Miki
× Sakaguchi, Miki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Treatment with interferon (IFN) for renal cell carcinoma was started in 1982 as one of the immunotherapies, but it is not so effective and no definite way of administration has been established yet. In thie report for the purpose of studying the action mechanism of IFN-α and IFN-γ, cytotoxic activity of peripheral blood mononuclear cells (PBMNCs) of the patients with renal cell carcinoma. When the patients' PBMNCs were treated with IFNs at various concentrations, difference was noted in each patient referring to IFNs and their concentrations for obtaining the maximum LAK-like activity using ACHN derived from human renal cell carcinoma as target cells. Further, the combined effect of cytotoxicity obtained by IFN-α and IFN- γ at their optimal concentration was additive in comparison with LAK-like activities upon therapy with IFN-α or IFN- γ alone respectivly. Further, when the action mechanism of IFN-γ was studied referring to subpopulation of the normal donor'PBMNCs by cell sorting, the strong LAK-like activity was induced on the lymphocyte fraction CD3(+)CD4(-). Further in consideration of cytokine concentrations measured and the above results, it seems that IFN-γ acts directly on the lymphocyte fraction CD3(+) CD4(-) to induce the LAK-like activity. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 39, 号 1-3, p. 34-38, 発行日 1994-10-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00034-P00038 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1994, 39(1-3), p.34-38 |