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Endothelin Receptors in Human Myometrium and Endometrium
http://hdl.handle.net/10069/16047
http://hdl.handle.net/10069/16047538651a8-4ba7-4338-9630-5948ae60697b
名前 / ファイル | ライセンス | アクション |
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acta41_01_04_t.pdf (1.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Endothelin Receptors in Human Myometrium and Endometrium | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | quantitative receptor autoradiography | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | emulsion autoradiography | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endothelin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ETA receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ETB receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human uterus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endometrium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myometrium | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Chavez, Railortega
× Chavez, Railortega |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated endothelin (ET) receptors in the endometrium and the myometrium obtained from pre-menopausal 39-, 40-, and 49-year-old women, using quantitative receptor and emulsion autoradiographic methods with 125I-endothelin- 1 (125I-ET-1) [radioligand for the ET receptors], BQ-123 [specific antagonist of the ETA receptor], and sarafotoxin S6c [agonist for the ETB receptor]. The radioligand binding reached a maximum at 36 hr of incubation and a plateau was maintained for up to 72 hr. No degradation of 125I-ET-1 during incubation was observed at 72 hr. In cold-ligand saturation binding studies 125I-ET-1 bound with a single affinity to the endometrium and the myometrium. In the myometrium the ETA receptor was found to be predominantly present, and also a considerable amount of the ETB receptor was quantified. There was a significant amount of the ETA and the ETB receptor in the endometrium, and the emulsion autroradiographic technique we used revealed the ETA and the ETB receptor to be on stroma cells and glandular epithelial cells, respectively. The existence of the the ETA and the ETB receptor in the endometrium and the myometrium supports the physiological significance of ET family of peptodes in the human uterus. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 41, 号 1-2, p. 28-34, 発行日 1996-06-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00028-P00034 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1996, 41(1-2), p.28-34 |