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Acebutolol and Diltiazem Improves Cardiac Function and Survival of Dogs Exposed to Hyperthermia
http://hdl.handle.net/10069/16104
http://hdl.handle.net/10069/161048143d068-dce7-4682-afae-c4b5c94eacd0
名前 / ファイル | ライセンス | アクション |
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acta43_01_08_t.pdf (579.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Acebutolol and Diltiazem Improves Cardiac Function and Survival of Dogs Exposed to Hyperthermia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | acebutolol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diltiazem | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cardiac function | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | induced hyperthermia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Fukui, Shigeru
× Fukui, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Whole body hyperthermia against malignant neoplasms has a limited temperature because of the clinical critical thermal maximum. This study was carried out to determine whether acebutolol or diltiazem could raise a critical temperature of dogs, Twentyfour male mongrel dogs were anesthetized with a large dose of morphine (2mg/kg), and randomly divided into 3 groups. Control (group C : n = 8) received only whole body hyperthermia (WBH). Group A (n = 8) received WBH and acebutolol , and Group D (n = 8) received WBH and diltiazem. The heart rate in control dogs increased by 53% at 43ツーC from base line, whereas it increased by only 7% and 9% in the presence of acebutolol and diltiazem, respectively. Similarly, both acebutolol and diltiazem significantly improved the myocardial oxygen extraction ratio and myocardial lactate extraction ratio so well as endocardial electrocardiogram ST segment elevation. Consequently, cardiac output and LVdp/dt max at 43ツーC were significantly improved by both acebutolol and diltiazem. Seventy-five percent and 87.5% of dogs administered acebutolol and diltiazem survived respectively, whereas none of control dogs survived at 44ツーC. In conclusion, acebutolol or diltiazem improves the myocardial oxygen demand-supply balance during hyperthermia. This effect would prevent circulatory collapse, and thus might raise CTMc above 42ツーC. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 43, 号 1-2, p. 44-49, 発行日 1998-06-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00044-P00049 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1998, 43(1-2), p.44-49 |