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Establishment of Photoaging Mouse Model by Long-Term Repetitive UVA Irradiation
http://hdl.handle.net/10069/16179
http://hdl.handle.net/10069/161796833501f-8515-4563-a8f6-96c7f720799a
名前 / ファイル | ライセンス | アクション |
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acta46_01_07_t.pdf (2.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Establishment of Photoaging Mouse Model by Long-Term Repetitive UVA Irradiation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | UVA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | photoaging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mouse model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | matrix metal loproteinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | elastin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RT-PCR | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Ogawa, Fumihide
× Ogawa, Fumihide× Shimizu, Kazuhiro× Jaebae, Sang× Hamasaki, Youichiro× Katayama, Ichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To clarify the mechanism of long-term repetitive UVA irradiation in photoaging of the skin, we evaluated albino hairless (SKH: HR1) mice by the irradiation with UVA (300-420nm ) for 12months. The output of irradiated UVA was 30J/cm2/day. Skin samples were taken from each group and examined at 0, 4, 8 and 12months. Morphologically, the structural changes of elastic fibers were observed in the dermis of irradiated group. In immunohistochemistry, tropoelastin, matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase (MMP9) were expressed in the fibroblasts in the dermis of photoaged skin. The expressions of tropoelastin, MMP2 and MMP9 mRNA in cultured fibroblasts were analyzed by RT-PCR. The expression of MMP9 mRNA was increased cultured fibroblast derived from irradiated mice. These results suggest that MMP9 is an important mediator in the development of photoaged skin for one-year repetitive exposure to UVA. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 46, 号 1-2, p. 39-47, 発行日 2001-06-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00039-P00047 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2001, 46(1-2), p.39-47 |