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Radiation and Ageing An Electron Microscopic Observation and Morphometrical Study on Lipofuscin in the Cerebellar Purkinje Cells, Myocardial Cells and Hepatic Cells
http://hdl.handle.net/10069/17472
http://hdl.handle.net/10069/17472ac91c71c-2881-4734-a597-f577ae2a6e82
名前 / ファイル | ライセンス | アクション |
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acta31_01-04_02_t.pdf (6.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-06-20 | |||||
タイトル | ||||||
タイトル | Radiation and Ageing An Electron Microscopic Observation and Morphometrical Study on Lipofuscin in the Cerebellar Purkinje Cells, Myocardial Cells and Hepatic Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kiyoto, Shinkai
× Kiyoto, Shinkai |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Four-week old and twelve-week old female Wistar rats were used in a long-term survival experiment undertaken as an investigation of ageing in the living body. Lipofuscin in the Purkinje cells, myocardial cells and hepatic cells of the rats was observed electron microscopically, and ageing in the living body was investigated by morphometrical analysis of lipofuscin. At the same time, the acceleration of ageing due to irradiation was investigated. As a result, the accumulation of lipofuscin with ageing in Purkinje cell and myocardial cell corresponding to a post-mitotic cell was shown in both irradiated and control groups. For that reason, it was conjectured that lipofuscin can be regarded as a morphological marker, although the accumulation of lipofuscin in hepatic cells having high regeneration potential was not shown. Therefore, it is difficult to regard lipofuscin in hepatic cells as a morphological marker. Comparing the 300R irradiated group with control group, a significant difference (p<0.05, p<0.01) concerning accumulation of lipofuscin was shown in only Purkinje cells. The correlation between accumulation of lipofuscin and ageing in 300R irradiated groups showed a more significant difference (p<0.05) than that in control groups, on the basis of regression lines calculated in the three kinds of cell. | |||||
書誌情報 |
Acta Medica Nagasakiensia 巻 31, 号 1/4, p. 14-30, 発行日 1986-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00014-P00030 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Medica Nagasakiensia. 1986, 31(1-4), p.14-30 |