WEKO3
アイテム
{"_buckets": {"deposit": "c5d06158-8a80-41b8-a9c3-cf32f84b218c"}, "_deposit": {"created_by": 2, "id": "14570", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "14570"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00014570", "sets": ["11"]}, "author_link": ["53587", "53595", "53586", "53589", "53592", "53594", "53593", "53591", "53590", "53596", "53588", "53585"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "1570", "bibliographicPageStart": "1558", "bibliographicVolumeNumber": "130", "bibliographic_titles": [{"bibliographic_title": "The Journal of investigative dermatology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Sensitization and challenge using DNFB induce contact hypersensitivity (CHS) with predominant type 1 helper (Th1) cell infiltration, whereas those using FITC generate CHS with Th2 cell infiltration. CHS results from inflammatory cell infiltration, a process that is highly regulated by the expression of multiple adhesion molecules. We attempted to determine the role of L-selectin and ICAM-1 in Th1- and Th2-type CHS induced by DNFB or FITC in mice lacking either L-selectin, ICAM-1, or both. Th1-type CHS induced by DNFB was inhibited by L-selectin and/or ICAM-1 deficiency, which was associated with reduced IFN-gamma expression. Similarly, Th2-type CHS induced by FITC was inhibited by L-selectin deficiency. However, Th2-type CHS was increased by ICAM-1 deficiency and accompanied by increased Th2 cytokine expression. Infiltration of in vitro-generated Th1 cells into the FITC-challenged skin decreased in ICAM-1-deficient mice, whereas in vitro-generated Th2 cell infiltration increased, suggesting that ICAM-1 mediates Th1 cell migration and that in the absence of ICAM-1, Th1 cell recruitment decreased, whereas relative Th2 cell migration increased. These results suggest that ICAM-1 mediates Th1 cell recruitment irrespective of DNFB or FITC and that L-selectin recruits Th1 cells in Th1-type CHS, whereas it recruits Th2 cells in Th2-type CHS.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "The Journal of investigative dermatology, 130(6), pp.1558-1570; 2010", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "20182448", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/jid.2010.25", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2010 The Society for Investigative Dermatology."}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00700733", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022202X", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "15231747", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ogawa, Asako"}], "nameIdentifiers": [{"nameIdentifier": "53585", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshizaki, Ayumi"}], "nameIdentifiers": [{"nameIdentifier": "53586", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanaba, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "53587", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogawa, Fumihide"}], "nameIdentifiers": [{"nameIdentifier": "53588", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara, Toshihide"}], "nameIdentifiers": [{"nameIdentifier": "53589", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Muroi, Eiji"}], "nameIdentifiers": [{"nameIdentifier": "53590", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takenaka, Motoi"}], "nameIdentifiers": [{"nameIdentifier": "53591", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimizu, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "53592", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hasegawa, Minoru"}], "nameIdentifiers": [{"nameIdentifier": "53593", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimoto, Manabu"}], "nameIdentifiers": [{"nameIdentifier": "53594", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tedder, Thomas F"}], "nameIdentifiers": [{"nameIdentifier": "53595", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Shinichi"}], "nameIdentifiers": [{"nameIdentifier": "53596", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JID130_1558.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "JID130_1558.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/14570/files/JID130_1558.pdf"}, "version_id": "eff80d0e-23e0-4901-b206-379c5e5d9b1c"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity."}]}, "item_type_id": "2", "owner": "2", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10069/24565", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-01-17"}, "publish_date": "2011-01-17", "publish_status": "0", "recid": "14570", "relation": {}, "relation_version_is_last": true, "title": ["The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity."], "weko_shared_id": 2}
The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity.
http://hdl.handle.net/10069/24565
http://hdl.handle.net/10069/24565674f04bb-1394-483c-b6c2-569642c0dee8
名前 / ファイル | ライセンス | アクション |
---|---|---|
JID130_1558.pdf (1.7 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-01-17 | |||||
タイトル | ||||||
タイトル | The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ogawa, Asako
× Ogawa, Asako× Yoshizaki, Ayumi× Yanaba, Koichi× Ogawa, Fumihide× Hara, Toshihide× Muroi, Eiji× Takenaka, Motoi× Shimizu, Kazuhiro× Hasegawa, Minoru× Fujimoto, Manabu× Tedder, Thomas F× Sato, Shinichi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Sensitization and challenge using DNFB induce contact hypersensitivity (CHS) with predominant type 1 helper (Th1) cell infiltration, whereas those using FITC generate CHS with Th2 cell infiltration. CHS results from inflammatory cell infiltration, a process that is highly regulated by the expression of multiple adhesion molecules. We attempted to determine the role of L-selectin and ICAM-1 in Th1- and Th2-type CHS induced by DNFB or FITC in mice lacking either L-selectin, ICAM-1, or both. Th1-type CHS induced by DNFB was inhibited by L-selectin and/or ICAM-1 deficiency, which was associated with reduced IFN-gamma expression. Similarly, Th2-type CHS induced by FITC was inhibited by L-selectin deficiency. However, Th2-type CHS was increased by ICAM-1 deficiency and accompanied by increased Th2 cytokine expression. Infiltration of in vitro-generated Th1 cells into the FITC-challenged skin decreased in ICAM-1-deficient mice, whereas in vitro-generated Th2 cell infiltration increased, suggesting that ICAM-1 mediates Th1 cell migration and that in the absence of ICAM-1, Th1 cell recruitment decreased, whereas relative Th2 cell migration increased. These results suggest that ICAM-1 mediates Th1 cell recruitment irrespective of DNFB or FITC and that L-selectin recruits Th1 cells in Th1-type CHS, whereas it recruits Th2 cells in Th2-type CHS. | |||||
書誌情報 |
The Journal of investigative dermatology 巻 130, 号 6, p. 1558-1570, 発行日 2010-06 |
|||||
出版者 | ||||||
出版者 | Nature Publishing Group | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022202X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15231747 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00700733 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20182448 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/jid.2010.25 | |||||
権利 | ||||||
権利情報 | © 2010 The Society for Investigative Dermatology. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of investigative dermatology, 130(6), pp.1558-1570; 2010 |