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Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals
http://hdl.handle.net/10069/25482
http://hdl.handle.net/10069/254828e78f94e-7b7e-4e26-9390-6084e692027f
名前 / ファイル | ライセンス | アクション |
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TJEM224_105.pdf (352.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-08-08 | |||||
タイトル | ||||||
タイトル | Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone mineral density | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Elderly | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteoporosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Screening | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tartrate-resistant acid phosphatase type 5b | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Irie, Sumiko
× Irie, Sumiko× Hayashida, Naomi× Shinkawa, Tetsuko× Taira, Yasuyuki× Sekitani, Yui× Teraoka, Seitaro× Hashiguchi, Kanami× Yoshida, Koji× Morishita, Michiko× Takamura, Noboru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4 ± 6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β = -0.005, p = 0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β = 0.001, p < 0.001), and triglyceride (β = -0.097, p = 0.016) in men, and with body mass index (β = -0.009, p = 0.025), alkaline phosphatase (β = 0.001, p < 0.001), calcium (β = -0.059, p = 0.039), and bone trabecular area ratio (β = -0.47, p = 0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women. | |||||
書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 224, 号 2, p. 105-110, 発行日 2011-04-30 |
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出版者 | ||||||
出版者 | Tohoku University Medical Press | |||||
出版者別言語 | ||||||
東北ジャーナル刊行会 | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00408727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13493329 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00863920 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1620/tjem.224.105 | |||||
権利 | ||||||
権利情報 | © 2011 Tohoku University Medical Press. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/32740 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Tohoku Journal of Experimental Medicine, 224(2), pp.105-110; 2011 |