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METHODS: The peritoneal cavity is a compartment in which immunological host-tumor interactions can occur. However, the role of lymphocytes in the peritoneal cavity of gastric cancer patients is unclear. We observed 64 patients who underwent gastrectomy for gastric cancer and 11 patients who underwent laparoscopic cholecystectomy for gallstones and acted as controls. Lymphocytes isolated from both peripheral blood and peritoneal lavage were analyzed for surface markers of lymphocytes and their cytokine production by flow cytometry. CD4 +CD25 high T cells isolated from the patient\u0027s peripheral blood were co-cultivated for 4 d with the intra-peritoneal lymphocytes, and a cytokine assay was performed. RESULTS: At gastrectomy, CCR7 - CD45RA - CD8 + effector memory T cells were observed in the peritoneal cavity. The frequency of CD4 + CD25 high T cells in both the peripheral blood and peritoneal cavity was elevated in patients at advanced stage [control vs stage IV in the peripheral blood: 6.89 (3.39-10.4) vs 15.34 (11.37-19.31), P \u003c 0.05, control vs stage IV in the peritoneal cavity: 8.65 (5.28-12.0) vs 19.56 (14.81-24.32), P \u003c 0.05]. On the other hand, the suppression was restored with CD4 + CD25 high T cells from their own peripheral blood. This study is the first to analyze lymphocyte and cytokine production in the peritoneal cavity in patients with gastric cancer. Immune regulation at advanced stage is reversible at the point of gastrectomy. 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Immunological milieu in the peritoneal cavity at laparotomy for gastric cancer
http://hdl.handle.net/10069/29378
http://hdl.handle.net/10069/2937861baeffb-6e71-4d1c-a29d-c7b981a9bc50
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-10-04 | |||||
タイトル | ||||||
タイトル | Immunological milieu in the peritoneal cavity at laparotomy for gastric cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gastric cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphocytes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritoneal cavity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Regulatory T cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoneda, Akira
× Yoneda, Akira× Ito, Shinichiro× Susumu, Seiya× Matsuo, Mitsutoshi× Taniguchi, Ken× Tajima, Yoshitsugu× Eguchi, Susumu× Kanematsu, Takashi× Nagata, Yasuhiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | AIM: To investigate the immunological repertoire in the peritoneal cavity of gastric cancer patients. METHODS: The peritoneal cavity is a compartment in which immunological host-tumor interactions can occur. However, the role of lymphocytes in the peritoneal cavity of gastric cancer patients is unclear. We observed 64 patients who underwent gastrectomy for gastric cancer and 11 patients who underwent laparoscopic cholecystectomy for gallstones and acted as controls. Lymphocytes isolated from both peripheral blood and peritoneal lavage were analyzed for surface markers of lymphocytes and their cytokine production by flow cytometry. CD4 +CD25 high T cells isolated from the patient's peripheral blood were co-cultivated for 4 d with the intra-peritoneal lymphocytes, and a cytokine assay was performed. RESULTS: At gastrectomy, CCR7 - CD45RA - CD8 + effector memory T cells were observed in the peritoneal cavity. The frequency of CD4 + CD25 high T cells in both the peripheral blood and peritoneal cavity was elevated in patients at advanced stage [control vs stage IV in the peripheral blood: 6.89 (3.39-10.4) vs 15.34 (11.37-19.31), P < 0.05, control vs stage IV in the peritoneal cavity: 8.65 (5.28-12.0) vs 19.56 (14.81-24.32), P < 0.05]. On the other hand, the suppression was restored with CD4 + CD25 high T cells from their own peripheral blood. This study is the first to analyze lymphocyte and cytokine production in the peritoneal cavity in patients with gastric cancer. Immune regulation at advanced stage is reversible at the point of gastrectomy. CONCLUSION: The immunological milieu in the peritoneal cavity of patients with advanced gastric cancer elicited a Th2 response even at gastrectomy, but this response was reversible. | |||||
書誌情報 |
World Journal of Gastroenterology 巻 18, 号 13, p. 1470-1478, 発行日 2012-04-07 |
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出版者 | ||||||
出版者 | WJG Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10079327 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3748/wjg.v18.i13.1470 | |||||
権利 | ||||||
権利情報 | ©2012 Baishideng Publishing Group Co., Limited. All rights reserved. | |||||
権利 | ||||||
権利情報 | © 1995-2012 Baishideng Publishing Group Co., Limited. Articles published by this Open-Access journal are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | World Journal of Gastroenterology, 18(13), pp.1470-1478; 2012 |