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Evaluation of the Safety and Adverse Effects of Goreisan/Wulingsan, a Traditional Japanese-Chinese Herbal Formulation (Kampo), in a Rat Model: a Toxicological Evaluation
http://hdl.handle.net/10069/34937
http://hdl.handle.net/10069/349378a9c763c-e49c-49e5-a180-6ec73319dea6
名前 / ファイル | ライセンス | アクション |
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TMH42_127.pdf (2.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-12-10 | |||||
タイトル | ||||||
タイトル | Evaluation of the Safety and Adverse Effects of Goreisan/Wulingsan, a Traditional Japanese-Chinese Herbal Formulation (Kampo), in a Rat Model: a Toxicological Evaluation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Histopathology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inhibition of intestinal motion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Kampo | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver function | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Toxicology | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ahmed, Selim
× Ahmed, Selim× Uchida, Ryuichi× Hussain, Maleeha× Kabir, ARM Luthful× Rahman, Mohammed Zakiur× Rahman, Mohammad Sharifur× Honda, Sumihisa× Rashid, Mohammad Abdur |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Diarrhea is the second leading cause of death among children less than 5 years of age. Most of these deaths occur in developing countries in the tropical areas of Africa and South Asia. Goreisan/Wulingsan, a formula of Japanese-Chinese medicinal herbs (Kampo), has been used for the treatment of diarrhea and vomiting from ancient times in East Asia. Therefore, we planned a randomized controlled clinical trial of Goreisan/Wulingsan in Bangladeshi children. Although it is believed to be safe in East Asia, information regarding its toxicity on animals is scarce. Since Goreisan/Wulingsan has never been used in Bangladesh, it was necessary to ensure the safety of the formula in an animal experiment. Rats were assigned to a control group (normal saline, n = 4) or various Goreisan/Wulingsan groups (n = 26) receiving doses of 1 to 8 mg/g/day (7.7 to 61.5 times the recommended pediatric dose) over a period of 25 days. Their activities and health conditions were observed until they were sacrificed, after which blood samples were collected for biochemical liver function tests. The kidneys, liver and heart tissue were collected for histopathological study. No lethality was observed during the experiment. All of the rats consumed the doses completely and no constipation was observed, suggesting the absence of any inhibitory effect on intestinal motion. Also, no abnormal neurological activity was detected, nor any significant elevation of AST, ALT or ALP levels, except for AST and ALT at the highest dose of 8 mg/g/day. Histopathological studies of the kidneys, liver and heart tissues revealed no abnormalities. In conclusion, our results showed that Goreisan/Wulingsan is safe for rats, thereby justifying the use of the drug in a human trial. | |||||
書誌情報 |
Tropical Medicine and Health 巻 42, 号 3, p. 127-132, 発行日 2014-09-10 |
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出版者 | ||||||
出版者 | 日本熱帯医学会 | |||||
出版者別言語 | ||||||
Japanese Society of Tropical Medicine | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13488945 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13494147 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2149/tmh.2014-04 | |||||
権利 | ||||||
権利情報 | c 2014 Japanese Society of Tropical Medicine | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Tropical Medicine and Health, 42(3), pp.127-132; 2014 |