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Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK- antibody- positive myasthenia gravis
http://hdl.handle.net/10069/35201
http://hdl.handle.net/10069/35201c48a7f90-02aa-4333-8cf1-a383fadefe16
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK604_Nakata.pdf (173.7 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2015-04-08 | |||||||
| タイトル | ||||||||
| タイトル | Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK- antibody- positive myasthenia gravis | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Associated autoimmune disease | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Muscle-specific receptor tyrosine kinase | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Myasthenia gravis | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Thymus | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Titin antibodies | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
中田, るか
× 中田, るか
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| 著者別名 | ||||||||
| 識別子Scheme | WEKO | |||||||
| 識別子 | 114625 | |||||||
| 姓名 | Nakata, Ruka | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background and purpose: The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. Methods: The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 MuSK-Ab-positive patients nationwide were investigated and were compared with those in AChR-Ab-positive patients followed at our institute (n = 83). As for the autoantibodies associated with thymoma, titin Abs were measured. Results: Thymoma was not present in any of the MuSK-Ab-positive patients but presented in 21 patients (25.3%) amongst the AChR-Ab-positive patients. Titin Abs were absent in MuSK-Ab-positive patients but positive in 25 (30.1%) of the AChR-Ab-positive patients. Concomitant autoimmune diseases were present in eight MuSK-Ab-positive patients (9.6%) amongst whom Hashimoto's thyroiditis and rheumatoid arthritis predominated, whereas 22 AChR-Ab-positive patients (26.5%) had one or more concomitant autoimmune diseases of which Graves' disease predominated. Conclusions: Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between MuSK-Ab-positive and AChR-Ab-positive MG were indicated, suggesting that, in contrast with AChR-Ab-positive MG, thymus does not seem to be involved in the pathogenic mechanisms of MuSK-Ab-positive MG. | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第604号 学位授与年月日:平成25年6月5日 | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Author： Nakata Ruka , Motomura Masakatsu , Masuda Tomoko , Shiraishi Hirokazu , Tokuda Masahiro , Fukuda Taku , Ando Takao ,Yoshimura Toshiro , Tsujihata Mitsuhiro , Kawakami Atsushi | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: European Journal of Neurology, 20(9), pp.1272-1276; 2013 | |||||||
| 書誌情報 |
European Journal of Neurology 巻 20, 号 9, p. 1272-1276, 発行日 2013-06-05 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 13515101 | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1111/ene.12169 | |||||||
| 権利 | ||||||||
| 権利情報 | c 2013 EFNS. | |||||||
| 権利 | ||||||||
| 権利情報 | This is the accepted version of the following article: European Journal of Neurology, 20(9), pp.1272-1276; 2013, which has been published in final form at http://dx.doi.org/10.1111/ene.12169 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 日本人MuSK抗体陽性重症筋無力症患者の胸腺組織と自己免疫疾患の合併 | |||||||
| 出版者 | ||||||||
| 出版者 | Blackwell Publishing | |||||||
| 関係URI | ||||||||
| 識別子タイプ | HDL | |||||||
| 関連識別子 | http://hdl.handle.net/10069/34114 | |||||||
| 学位名 | ||||||||
| 学位名 | 博士(医学) | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 17301 | |||||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2013-06-05 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲医歯薬第604号 | |||||||
| 学位の種類 | ||||||||
| 値 | 課程博士 | |||||||
| 引用 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Nagasaki University (長崎大学), 博士(医学) (2013-06-05) | |||||||
