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International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus
http://hdl.handle.net/10069/35872
http://hdl.handle.net/10069/35872c5e12ddd-6efc-4866-80a0-64d25abe4e7d
名前 / ファイル | ライセンス | アクション |
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DRU21-22_30.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-10-02 | |||||
タイトル | ||||||
タイトル | International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aspergillus fumigatus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Azole resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Invasive aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Voriconazole | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Verweij, Paul E.
× Verweij, Paul E.× Ananda-Rajah, Michelle× Andes, David× Arendrup, Maiken C.× Bruggemann, Roger J.× Chowdhary, Anuradha× Cornely, Oliver A.× Denning, David W.× Groll, Andreas H.× Izumikawa, Koichi× Kullberg, Bart Jan× Lagrou, Katrien× Maertens, Johan× Meis, Jacques F.× Newton, Pippa× Page, Iain× Seyedmousavi, Seyedmojtaba× Sheppard, Donald C.× Viscoli, Claudio× Warris, Adilia× Donnelly, J. Peter |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | An international expert panel was convened to deliberate the management of azole-resistant aspergillosis. In culture-positive cases, in vitro susceptibility testing should always be performed if antifungal therapy is intended. Different patterns of resistance are seen, with multi-azole and pan-azole resistance more common than resistance to a single triazole. In confirmed invasive pulmonary aspergillosis due to an azole-resistant Aspergillus, the experts recommended a switch from voriconazole to liposomal amphotericin B (L-AmB; AmbisomeR). In regions with environmental resistance rates of ?10%, a voriconazole-echinocandin combination or L-AmB were favoured as initial therapy. All experts recommended L-AmB as core therapy for central nervous system aspergillosis suspected to be due to an azole-resistant Aspergillus, and considered the addition of a second agent with the majority favouring flucytosine. Intravenous therapy with either micafungin or L-AmB given as either intermittent or continuous therapy was recommended for chronic pulmonary aspergillosis due to a pan-azole-resistant Aspergillus. Local and national surveillance with identification of clinical and environmental resistance patterns, rapid diagnostics, better quality clinical outcome data, and a greater understanding of the factors driving or minimising environmental resistance are areas where research is urgently needed, as well as the development of new oral agents outside the azole drug class. | |||||
書誌情報 |
Drug Resistance Updates 巻 21-22, p. 30-40, 発行日 2015-07 |
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出版者 | ||||||
出版者 | Churchill Livingstone, 21-22, pp.30-40; 2015 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13687646 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.drup.2015.08.001 | |||||
権利 | ||||||
権利情報 | c (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Drug Resistance Updates |