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This study aims to clarify HIV serostatus in this group and elucidate risk factors for intra-marital HIV transmission. \nMethods: In 2012, we enrolled a group of HIV-positive married men registered at the HIV outpatient clinic of a referral hospital in northern Vietnam, along with their wives. \nSociodemographic, behavioural and clinical data were collected from men and wives. HIV serodiscordant couples were followed until March 2014 to determine seroconversion rate. A phylogenetic analysis was performed based on env V3 sequence to detail cluster formation among men. Results: Of the 163 HIV-positive men enrolled in the study, 101 (62.0%) had wives testing HIV-negative. Half of men reported injecting drug use (IDU) as a likely transmission route. Couples reported a high incidence of unprotected sexual intercourse prior to diagnosis; the median (inter quartile range) was 4 (4?8) times per month. Only 17 couples (10.4%) reported using condoms during at least half these instances. 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High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam
http://hdl.handle.net/10069/37024
http://hdl.handle.net/10069/3702474540d54-d683-40eb-a8b5-3def718b1995
名前 / ファイル | ライセンス | アクション |
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ISYK896_Sawada.pdf (746.3 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-01-31 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | High Proportion of HIV Serodiscordance among HIV-Affected Married Couples in Northern Vietnam | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
澤田, 郁美
× 澤田, 郁美 |
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著者別名 | ||||||
姓名 | Sawada, Ikumi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: Little is known about the state of HIV transmission among married couples in Vietnam. This study aims to clarify HIV serostatus in this group and elucidate risk factors for intra-marital HIV transmission. Methods: In 2012, we enrolled a group of HIV-positive married men registered at the HIV outpatient clinic of a referral hospital in northern Vietnam, along with their wives. Sociodemographic, behavioural and clinical data were collected from men and wives. HIV serodiscordant couples were followed until March 2014 to determine seroconversion rate. A phylogenetic analysis was performed based on env V3 sequence to detail cluster formation among men. Results: Of the 163 HIV-positive men enrolled in the study, 101 (62.0%) had wives testing HIV-negative. Half of men reported injecting drug use (IDU) as a likely transmission route. Couples reported a high incidence of unprotected sexual intercourse prior to diagnosis; the median (inter quartile range) was 4 (4?8) times per month. Only 17 couples (10.4%) reported using condoms during at least half these instances. Multivariable analysis revealed IDU history among men was independently associated with HIV-negative wives (adjusted OR 0.31; 95% CI 0.10?0.95, p=0.041). Phylogenetic analysis of 80 samples indicated CRF01_AE. Of these, 69 (86.3%) clustered with IDU-associated viruses from Vietnam. No HIV seroconversion was identified during a follow-up of 61 serodiscordant couples, with 126.5 person-years of observation during which HIV-infected men were on antiretroviral drug therapy (ART). Conclusion: High HIV serodiscordance was observed among HIV-affected married couples in northern Vietnam. A large number of at-risk wives therefore remain HIV-negative and can be protected with measures including proper use of ART if couples are made aware of the serodiscordance through screening. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第896号 学位授与年月日:平成29年1月31日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Ikumi Sawada, Junko Tanuma, Cuong Duy Do, Tra Thu Doan, Quynh Phuong Luu, Lan Anh Thi Nguyen, Tuong Van Thi Vu, Tuan Quang Nguyen, Naho Tsuchiya, Teiichiro Shiino, Lay-Myint Yoshida, Thanh Thuy Thi Pham, Koya Ariyoshi, Shinichi Oka | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: PLOS ONE, 10(4), e0125299; 2015 | |||||
書誌情報 |
PLOS ONE 巻 10, 号 4, p. e0125299, 発行日 2017-01-31 |
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EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19326203 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0125299 | |||||
権利 | ||||||
権利情報 | c 2015 Sawada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 北部ベトナムのHIVに感染した夫婦におけるHIVの血清学的不一致率は高い | |||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/36865 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-01-31 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第896号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2017-01-31) |