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Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front
http://hdl.handle.net/10069/38325
http://hdl.handle.net/10069/3832541944273-e1f8-48e8-87c6-ab0737947f5e
名前 / ファイル | ライセンス | アクション |
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ISYK1045_Honda.pdf (1.0 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2019-01-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oral squamous cell carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cadherin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epithelial-mesenchymal transition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Multivariate analysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prognosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
本田, 由
× 本田, 由 |
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著者別名 | ||||||
姓名 | Honda, Yuu | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Epithelial-mesenchymal transition (EMT) is a significant process in the invasion and metastasis of cancers including oral squamous cell carcinoma (OSCC), and the cadherin switch has been identified as one of the hallmarks of EMT. The aim of the present study was to evaluate the significance of the cadherin switch in the prognosis of OSCC and generate a model for prognostic predictions. Seventy-six biopsy and/or initial surgical specimens from OSCC patients were immunohistochemically analyzed for the expression of E-cadherin and N-cadherin in either overall OSCC cells in tumor nests or in OSCC cells at the invasive front. Among 76 OSCC cases, overall OSCC cells in tumor nests were negative for the expression of E-cadherin in 10 cases and positive for that of N-cadherin in 53 cases. Among 10 cases negative for the expression of E-cadherin, 4 cases were positive for that of N-cadherin. In OSCC cells at the invasive front, the expression of E-cadherin was negative in 62 cases, while that of N-cadherin was positive in 39 cases. Among 62 cases negative for the expression of E-cadherin, 33 cases were positive for that of N-cadherin. A logistic regression analysis showed that a model using the evaluation of N-cadherin expression in overall OSCC cells in tumor nests with a cut-off point of 70 years old was the best fit model. These results suggest that N-cadherin has significant value in prognostic predictions for OSCC patients. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1045号 学位授与年月日:平成30年3月20日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Yuu Ozaki-Honda, Sachiko Seki, Mutsunori Fujiwara, Masaaki Matsuura, Shuichi Fujita, Hisazumi Ikeda, Masahiro Umeda, Takao Ayuse, Tohru Ikeda | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Cancer Microenvironment, 10(1-3), pp.87?94; 2017 | |||||
書誌情報 |
Cancer Microenvironment 巻 10, 号 1-3, p. 87-94, 発行日 2018-03-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18752292 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18752284 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12307-017-0201-1 | |||||
権利 | ||||||
権利情報 | c Springer Science+Business Media B.V. 2017 | |||||
権利 | ||||||
権利情報 | The final publication is available at link.springer.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 腫瘍胞巣全体もしくは浸潤先端におけるE-cadherinおよびN-cadherinの発現程度を用いた口腔扁平上皮癌患者の予後予測 | |||||
出版者 | ||||||
出版者 | Springer Netherlands | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/38087 | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1045号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(歯学) (2018-03-20) |