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Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: a cross-sectional study
http://hdl.handle.net/10069/38863
http://hdl.handle.net/10069/38863d9f18661-f1a2-4001-ba90-b665beed9057
名前 / ファイル | ライセンス | アクション |
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Aging11_663.pdf (447.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-02-22 | |||||
タイトル | ||||||
タイトル | Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: a cross-sectional study | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD34-positive cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Consumptive reduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Elderly men | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Height | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vascular maintenance | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimizu, Yuji
× Shimizu, Yuji× Yamanashi, Hirotomo× Noguchi, Yuko× Koyamatsu, Jun× Nagayoshi, Mako× Kiyoura, Kairi× Fukui, Shoichi× Tamai, Mami× Kawashiri, Shin-Ya× Arima, Kazuhiko× Maeda, Takahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent studies have revealed an inverse association between height and cardiovascular disease and that endothelial progenitor cells(CD34-positive cells) contribute to vascular maintenance, which is associated with cardiovascular disease. However,evidence of the association between height and CD34-positive positive cells among elderly participants is limited. To assess this association, we conducted a cross-sectional study of 231 elderly Japanese men aged 65-69. Since enhanced production of circulating CD34-positive cells in response to endothelial injury might act have a strong confounding effect on the association between height and circulating CD34-positive cells, the median value for the levels of these cells (0.93 cells/μL) was used to stratify the participants.Multivariable linear regression analysis demonstrated that height was significantly positively associated with circulating CD34-positive cells for those participants with low levels of circulating CD34-positive cells (n=114) but not for those with higher levels (n=117), with a multi-adjusted standardized parameter estimate (β) of 0.27 (p=0.008) for low and 0.11 (0.275) for higher circulating CD34-positive cell levels. The positive association is limited to participants with relatively low circulating CD34-positive cell levels, whose productivity of these cells is not activated. Our findings indicate that height is an indicator of vascular maintenance capability in elderly Japanese men. |
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書誌情報 |
Aging 巻 11, 号 2, p. 663-672, 発行日 2019-01-29 |
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出版者 | ||||||
出版者 | Impact Journals LLC | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09182918 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19454589 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/aging.101768 | |||||
権利 | ||||||
権利情報 | c Shimizu et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Aging, 11(2), pp.663-672; 2019 |