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Brugia malayi in Mastomys natalensis : Effect of Immunostimulators on Establishment and Course of Infection
http://hdl.handle.net/10069/4597
http://hdl.handle.net/10069/4597413a19b1-8bcf-4d53-a2d3-d022d0aad684
名前 / ファイル | ライセンス | アクション |
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tm34_02_03_t.pdf (792.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | Brugia malayi in Mastomys natalensis : Effect of Immunostimulators on Establishment and Course of Infection | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Murthy, P. K.
× Murthy, P. K.× Haq, W.× Tyagi, K.× Mathur, K. B.× Chatterjee, R. K. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Effect of three immunomodulators (IMS), muramyl dipeptide (MDP), Freund's complete adjuvant (FCA) and a newly synthesized sugar free immunomodulator (CDRI Comp. No. 84/201) on the establishment and course of Brugia malayi infection in Mastomys natalensis was evaluated. These immunomodulators were administered on three occasions (days -10, 0 and +15 of larval exposure) by subcutaneous route. All the three immunostimulators caused prolongation of prepatent period of the infection, the longest being observed with Comp. 84/201 (136.6 days) followed by MDP (120 days) and FCA (118.82 days). Comp. 84/201 and MDP treated animals revealed significantly suppressed microfilaraemia (P<0.01) and less percentage of worm recovery over untreated infected controls. It is, thus, surmised that establishment of filarial infection be affected by immunomodulators and a Comp. 84/201, a non-pyrogenic immunomodulator holds promise for the purpose. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 34, 号 2, p. 63-69, 発行日 1992-06-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00063-P00069 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 34(2). p63-69, 1992 |