Terminalia ferdinandiana Exell. Extracts inhibit the growth of body odour-forming bacteria
Author(s)
McManus, K
Wood, A
Wright, MH
Matthews, B
Greene, AC
Cock, IE
Year published
2017
Metadata
Show full item recordAbstract
OBJECTIVE: Terminalia ferdinandiana extracts are potent growth
inhibitors of many bacterial pathogens. They may also inhibit the
growth of malodour-producing bacteria and thus be useful deodorant
components, although this is yet to be tested.
METHODS: Terminalia ferdinandiana fruit and leaf solvent extracts
were investigated by disc diffusion and liquid dilution MIC assays
against the most significant bacterial contributors to axillary and
plantar malodour formation. Toxicity was determined using the
Artemia franciscana nauplii bioassay. Non-targeted HPLC separation
of the methanolic leaf extract coupled to high-resolution ...
View more >OBJECTIVE: Terminalia ferdinandiana extracts are potent growth inhibitors of many bacterial pathogens. They may also inhibit the growth of malodour-producing bacteria and thus be useful deodorant components, although this is yet to be tested. METHODS: Terminalia ferdinandiana fruit and leaf solvent extracts were investigated by disc diffusion and liquid dilution MIC assays against the most significant bacterial contributors to axillary and plantar malodour formation. Toxicity was determined using the Artemia franciscana nauplii bioassay. Non-targeted HPLC separation of the methanolic leaf extract coupled to high-resolution time-of- flight (TOF) mass spectroscopy was used for the identification and characterization of individual components in the extract. RESULTS: The T. ferdinandiana leaf extracts were the most potent bacterial growth inhibitors. The leaf methanolic extract was particularly potent, with low MIC values against C. jeikeium (233 lg mL 1 ), S. epidermidis (220 lg mL 1 ), P. acnes (625 lg mL 1 ) and B. linens (523 lg mL 1 ). The aqueous and ethyl acetate leaf extracts were also potent growth inhibitors of C. jeikeium and S. epidermidis (MICs < 1000 lg mL 1 ). In comparison, the fruit extracts were substantially less potent antibacterial agents, although still with MIC values indicative of moderate growth inhibitory activity. All T. ferdinandiana leaf extracts were non-toxic in the Artemia franciscana bioassay. Non-biased phytochemical analysis of the methanolic leaf extract revealed the presence of high levels of and high diversity of tannins and high levels of the flavone luteolin. CONCLUSION: The low toxicity of the T. ferdinandiana leaf extracts and their potent growth inhibition of axillary and plantar malodour-producing bacteria indicate their potential as deodorant
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View more >OBJECTIVE: Terminalia ferdinandiana extracts are potent growth inhibitors of many bacterial pathogens. They may also inhibit the growth of malodour-producing bacteria and thus be useful deodorant components, although this is yet to be tested. METHODS: Terminalia ferdinandiana fruit and leaf solvent extracts were investigated by disc diffusion and liquid dilution MIC assays against the most significant bacterial contributors to axillary and plantar malodour formation. Toxicity was determined using the Artemia franciscana nauplii bioassay. Non-targeted HPLC separation of the methanolic leaf extract coupled to high-resolution time-of- flight (TOF) mass spectroscopy was used for the identification and characterization of individual components in the extract. RESULTS: The T. ferdinandiana leaf extracts were the most potent bacterial growth inhibitors. The leaf methanolic extract was particularly potent, with low MIC values against C. jeikeium (233 lg mL 1 ), S. epidermidis (220 lg mL 1 ), P. acnes (625 lg mL 1 ) and B. linens (523 lg mL 1 ). The aqueous and ethyl acetate leaf extracts were also potent growth inhibitors of C. jeikeium and S. epidermidis (MICs < 1000 lg mL 1 ). In comparison, the fruit extracts were substantially less potent antibacterial agents, although still with MIC values indicative of moderate growth inhibitory activity. All T. ferdinandiana leaf extracts were non-toxic in the Artemia franciscana bioassay. Non-biased phytochemical analysis of the methanolic leaf extract revealed the presence of high levels of and high diversity of tannins and high levels of the flavone luteolin. CONCLUSION: The low toxicity of the T. ferdinandiana leaf extracts and their potent growth inhibition of axillary and plantar malodour-producing bacteria indicate their potential as deodorant
View less >
Journal Title
International Journal of Cosmetic Science
Volume
39
Issue
5
Subject
Medicinal and biomolecular chemistry
Natural products and bioactive compounds
Clinical sciences
Allied health and rehabilitation science