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CD204‑positive macrophages accumulate in breast cancer tumors with high levels of infiltrating lymphocytes and programmed death ligand‑1 expression
http://hdl.handle.net/10076/00019693
http://hdl.handle.net/10076/00019693ac161928-6614-484d-a6a5-5bcdd2d7b15d
名前 / ファイル | ライセンス | アクション |
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2020DM0338 (676.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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公開日 | 2021-06-29 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | CD204‑positive macrophages accumulate in breast cancer tumors with high levels of infiltrating lymphocytes and programmed death ligand‑1 expression | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | breast cancer | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | tumor‑infiltrating lymphocytes | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | programmed death ligand‑1 | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | tumor‑associated macrophages | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | CD204+ macrophages | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
資源タイプ | doctoral thesis | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
長野, 真由子
× 長野, 真由子
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Although immunotherapy has been demonstrated to be promising in triple‑negative (TN) breast cancer (BC), most BC cases are classified as non‑TN. To enrich the responders for immunotherapy regardless of their subtypes, classification based on tumor‑infiltrating lymphocyte (TIL) levels and programmed death ligand‑1 (PD‑L1) status may be useful. However, this classification has not been fully applied to BC. Furthermore, suppressive subsets in the local tumor microenvironment, such as tumor‑associated macrophages (TAMs), which promote tumor progression, cannot be ignored to overcome immunotherapy resistance. The aims of the present study were to classify primary BC cases based on the TIL levels and PD‑L1 status, and to identify suppressive immune subsets in each categorized group. A retrospective analysis of 73 patients with invasive BC was performed. The frequency of TILs was evaluated in HE‑stained slides (10% cutoff), and PD‑L1 levels (SP142; 1% cut off), as well as immune subsets (CD3+, CD8+, FOXP3+, CD20+, CD68+ and CD204+cells) were assessed using immunohistochemistry. It was revealed that 22% (16/73) of the tumors were categorized asTIL+PD‑L1+, of which 69% (11/16) were TN type. By contrast, 66% (48/73) of the tumors were categorized as TIL‑PD‑L1‑, of which 77% (37/48) were HR+ and HER2‑ types. The number of CD204+ M2‑type macrophages was significantly associated with high histological grade (P=0.0246) and high Ki‑67(P=0.0152), whereas CD68+ macrophages were not associated with these factors. Furthermore, CD204+ macrophages and FOXP3+ Tregs accumulated in 88% (14/16) and 63% (10/16) of TIL+PD‑L1+ tumors, respectively, compared with 20.8%(10/48) and 27.1% (13/48) of TIL‑PD‑L1‑ tumors. In conclusion, 22% of BC tumors were classified as TIL+PD‑L1+ (69% were TN), which were enriched with suppressive immune subsets. These cell types may serve as potential novel immunotherapeutic targets. | |||||||||||
言語 | en | |||||||||||
内容記述 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 本文/Departments of Breast Surgery Mie University Graduate School of Medicine | |||||||||||
内容記述 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 10p | |||||||||||
書誌情報 |
発行日 2021-03-25 |
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DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.3892/ol.2020.12297 | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
出版者 | ||||||||||||
出版者 | 三重大学 | |||||||||||
出版者(ヨミ) | ||||||||||||
ミエダイガク | ||||||||||||
学位名 | ||||||||||||
学位名 | 博士(医学) | |||||||||||
学位授与機関 | ||||||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||||
学位授与機関識別子 | 14101 | |||||||||||
学位授与機関名 | 三重大学 | |||||||||||
学位授与年月日 | ||||||||||||
学位授与年月日 | 2021-03-25 | |||||||||||
学位授与番号 | ||||||||||||
学位授与番号 | 甲医学第2064号 | |||||||||||
ノート | ||||||||||||
ONCOLOGY LETTERS 21(1): 36, 2021に掲載 | ||||||||||||
資源タイプ(三重大) | ||||||||||||
Doctoral Dissertation / 博士論文 |