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• Author/Creator:Tavassoly, Iman.
  
• Title:Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells [electronic resource] : Mathematical Modeling and Experimental Observations / by Iman Tavassoly.
  
• ISBN:9783319149622
  
• Publication:Cham : Springer International Publishing : Imprint: Springer, 2015.
  
• Physical Description:XXI, 79 p. 47 illus., 46 illus. in color : online resource.
  
• Links:Online book
  

• Yale Holdings

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  • Location:Yale Internet Resource
    Information about Off Campus Access
    
    
  • Call Number: None
    
  • Status:No information available 
  • Notes: Online Resource
    

   
• Local Notes:Access is available to the Yale community.
  
• Access and use:Access restricted by licensing agreement.
• Summary:This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.
  
• In_:Springer eBooks
  
• Variant and related titles:Springer eBooks.
  
• Other formats:Printed edition:
  
• Format:Book
• Series:Springer Theses, Recognizing Outstanding Ph.D. Research,
  Springer Theses, Recognizing Outstanding Ph.D. Research.
  
• Contents:Introduction -- Mathematical Modeling of the Interplay of Autophagy and Apoptosis -- An Experimental Framework to Study the Dynamics of Autophagic Response -- Conclusions -- Source Code.
  
• Subjects:Oncology.
  Bioinformatics.
  Cytology.
  Biomedical materials.
  
• Also listed under:SpringerLink (Online service)