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• Title:Computational Systems Toxicology [electronic resource] / edited by Julia Hoeng, Manuel C. Peitsch.
  
• ISBN:9781493927784
  
• Edition:1st ed. 2015.
  
• Publication:New York, NY : Springer New York : Imprint: Humana Press, 2015.
  
• Physical Description:1 online resource (X, 430 p.) 109 illus., 96 illus. in color.
  
• Links:Online book
  

• Yale Holdings

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  • Location:Yale Internet Resource
    Information about Off Campus Access
    
    
  • Call Number: None
    
  • Status:No information available 
  • Notes: Online resource
    

   
• Local Notes:Access is available to the Yale community.
  
• Access and use:Access restricted by licensing agreement.
• Summary:This detailed volume explores key state-of-the-art computational applications that are crucial in Systems Toxicology.  The recent technological developments in experimental biology and multi-omics measurements that enable Systems Biology and Systems Toxicology can only be fully leveraged by the application of a broad range of computational approaches ranging from data management to mathematical modeling. Taking this into account, chapters in this book cover data management and processing, data analysis, biological network building and analysis, as well as the application of computational methods to toxicological assessment. Written for the Methods in Pharmacology and Toxicology series, Computational Systems Toxicology includes the kind of key practical advice that will aid readers in furthering our knowledge of toxic substances and reactions to them.
  
• In_:Springer eBooks
  
• Variant and related titles:Springer protocols (Series)
  
• Other formats:Printed edition:
  
• Format:Book
• Series:Methods in Pharmacology and Toxicology,
  Methods in Pharmacology and Toxicology,
  
• Contents:The Adverse Outcome Pathway: A Conceptual Framework to Support Toxicity Testing in the 21st Century -- Metabolic Pathway Databases: A Word of Caution -- Causal Biological Network Database: A Comprehensive Platform of Causal Biological Network Models Focused on the Pulmonary and Vascular Systems -- Data Sources for Signature Discovery in Toxicology -- Data Management and Processing in Toxicoinformatics: From Chemical Databases to Automatic Extraction of Unstructured Resources -- Using a Crowdsourcing Approach for Network Verification -- Toxicological Assessment Via Gene Network Analysis -- Weaving Knowledge into Biological Pathways in a Collaborative Manner -- Pathway Analysis and Machine Learning as Tools in Systems Toxicology -- Quantifying the Biological Impact of Active Substances Using Causal Network Models -- Analysis of Proteomic Data for Toxicological Applications -- Xenobiotic Metabolism Activation as a Biomarker of Cigarette Smoke Exposure Response -- High-Content Screening: Understanding and Managing Mechanistic Data to Better Predict Toxicity -- A Systems Toxicology Approach to Investigating the Cardiovascular Effects of Cigarette Smoke and Environmental Pollutants in ApoE-Deficient Mice -- Computational Data Integration in Toxicogenomics -- Aerosol Dosimetry Modeling Using Computational Fluid Dynamics.
  
• Subjects:Medicine.
  Pharmacology.
  Systems biology.
  
• Also listed under:Hoeng, Julia. editor.
  Peitsch, Manuel C. editor.
  SpringerLink (Online service)