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• Title:The role of DNA damage and repair in cell aging / volume editors, Barbara A. Gilchrest, Vilhelm A. Bohr.
  
• ISBN:044450494X
  9780444504944
  
• Edition:1st ed.
  
• Published/Created:Amsterdam ; New York : Elsevier, 2001.
  
• Physical Description:1 online resource (vii, 257 pages) : illustrations (some color).
  
• Links:Online book
  

• Yale Holdings

  Holdings Record Display

  • Location:Yale Internet Resource
    Information about Off Campus Access
    
    
  • Call Number: None
    
  • Status:No information available 
  • Notes: Online resource
    

   
• Local Notes:Access is available to the Yale community.
  
• Notes:Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010.
  English.
  Description based on print version record.
  
• Access and use:Access restricted by licensing agreement.
• Summary:Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.
  
• Variant and related titles:Elsevier ScienceDirect All Books. OCLC KB.
  
• Other formats:Print version: Role of DNA damage and repair in cell aging. 1st ed. Amsterdam ; New York : Elsevier, 2001
  
• Format:Book
• Series:Advances in cell aging and gerontology ; v. 4
  Advances in cell aging and gerontology ; v. 4.
  
• BibliographyIncludes bibliographical references.
  
• Subjects:DNA repair.
  Apoptosis.
  DNA damage.
  DNA repair.
  
• Subjects (Medical): DNA Damage.
  DNA Repair.
  
• Also listed under:Gilchrest, Barbara A.
  Bohr, Vilhelm A.