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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration

http://hdl.handle.net/10091/00022479
http://hdl.handle.net/10091/00022479
6bb4ffeb-af8c-4117-95a4-bb5465d92fad
名前 / ファイル ライセンス アクション
nanomaterials-07-00046.pdf nanomaterials-07-00046.pdf (15.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-04
タイトル
タイトル In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration
言語
言語 eng
DOI
関連識別子 https://doi.org/10.3390/nano7020046
関連名称 10.3390/nano7020046
キーワード
主題 tissue engineering, bone regeneration, carbon nanotube
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tanaka, Manabu

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en Tanaka, Manabu

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Sato, Yoshinori

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en Sato, Yoshinori

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Zhang, Mei

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en Zhang, Mei

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Haniu, Hisao

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en Haniu, Hisao

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Okamoto, Masanori

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en Okamoto, Masanori

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Aoki, Kaoru

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en Aoki, Kaoru

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Takizawa, Takashi

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en Takizawa, Takashi

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Yoshida, Kazushige

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Sobajima, Atsushi

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en Sobajima, Atsushi

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Kamanaka, Takayuki

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en Kamanaka, Takayuki

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Kato, Hiroyuki

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en Kato, Hiroyuki

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Saito, Naoto

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信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
信州大学研究者総覧へのリンク
氏名 Okamoto, Masanori
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html
信州大学研究者総覧へのリンク
氏名 Aoki, Kaoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html
信州大学研究者総覧へのリンク
氏名 Takizawa, Takashi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OhTebVym.html
信州大学研究者総覧へのリンク
氏名 Yoshida, Kazushige
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ZeyVPUym.html
信州大学研究者総覧へのリンク
氏名 Kato, Hiroyuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html
信州大学研究者総覧へのリンク
氏名 Saito, Naoto
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html
出版者
出版者 MDPI AG
引用
内容記述 NANOMATERIALS. 7(2):46 (2017)
書誌情報 NANOMATERIALS

巻 7, 号 2, p. 46, 発行日 2017-02
抄録
内容記述 Carbon nanotubes (CNTs) have attracted a great deal of attention for the biological and medical science fields because of their characteristic physical and biological properties. In this study, we investigated the capacity of the 3D porous CNT scaffold (CNT porous block; CNTp) for bone regenerative medicine. Surface observations using a scanning electron microscope (SEM), crystal depositions on the surface of CNTps immersed in simulated body fluid (SBF), and evaluations of protein adsorption and controlled releasing were conducted to assess physical properties. The cell proliferation and cell morphology were observed using SEM and fluorescent microscopy. CNTps were implanted into critical-size mouse calvarial defects and evaluated for their osteoconductive ability and in vivo controlled release of recombinant human BMP-2 (rhBMP-2). Interconnected porous HA ceramics (IP-CHAs) were used for comparison. CNTps have multiporous structures with interporous connections with networks of multiwalled CNTs. Crystals containing calcium and phosphate were deposited in CNTps and on the surface of the CNT networks by immersing CNTps in SBF. CNTps adsorbed more significantly and released protein more gradually than IP-CHAs. Preosteoblasts seeded onto CNTps filled pores with stretched actin filaments and filopodia. Compared with IP-CHAs, CNTps showed significantly higher cell proliferation, better osteoconduction, and more bone generation with rhBMP-2. In this study, CNTps demonstrated good osteoconductive ability, cell attachment and proliferation capacity, and growth factor retaining ability. CNTps have the potential not only as artificial bones for the treatment of bone defects, but also as scaffolds for regenerative medicine using tissue engineering approaches.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ EISSN
収録物識別子 2079-4991
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/28336879
関連名称 28336879
権利
権利情報 © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000400761600024
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