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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

A Splice Variant of ASC Regulates IL-1 beta Release and Aggregates Differently from Intact ASC

http://hdl.handle.net/10091/10812
http://hdl.handle.net/10091/10812
2d581490-c0d6-41ee-845a-500be624c22f
名前 / ファイル ライセンス アクション
Splice_Variant_ASC_Regulates.pdf Splice_Variant_ASC_Regulates.pdf (1.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-12-02
タイトル
タイトル A Splice Variant of ASC Regulates IL-1 beta Release and Aggregates Differently from Intact ASC
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1155/2009/287387
関連名称 10.1155/2009/287387
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Matsushita, Kazuhiko

× Matsushita, Kazuhiko

en Matsushita, Kazuhiko

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Takeoka, Michiko

× Takeoka, Michiko

en Takeoka, Michiko

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Sagara, Junji

× Sagara, Junji

en Sagara, Junji

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Itano, Naoki

× Itano, Naoki

en Itano, Naoki

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Kurose, Yuka

× Kurose, Yuka

en Kurose, Yuka

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Nakamura, Akihiro

× Nakamura, Akihiro

en Nakamura, Akihiro

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Taniguchi, Shun'ichiro

× Taniguchi, Shun'ichiro

en Taniguchi, Shun'ichiro

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信州大学研究者総覧へのリンク
氏名 Taniguchi, Shun'ichiro
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HCyUHCDV.html
出版者
出版者 Hindawi Publishing Corporation
引用
内容記述 Mediators of Inflammation. 2009:287387 (2009)
書誌情報 Mediators of Inflammation

巻 2009, 発行日 2009
内容記述
内容記述タイプ Other
内容記述 Copyright (c) 2009 Kazuhiko Matsushita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
抄録
内容記述 The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), respectively, and exon 2 encodes a proline and glycine-rich (PGR) domain. Here, we identified a variant ASC protein (vASC) lacking the PGR domain that was smaller than full length ASC (fASC) derived from fully transcribed mRNA and searched for differences in biochemical and biological nature. Both fASC and vASC were found to activate procaspase-1 to a similar degree, but the efficiency of IL-1 beta excretion was significantly higher for vASC. There was also a marked structural difference observed in the fibrous aggregates formed by fASC and vASC. These results suggest that although the PGR domain is dispensable for procaspase-1 activation, it plays an important role in the regulation of the molecular structure and activity of ASC.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0962-9351
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10844172
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19759850
関連名称 19759850
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270782500001
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