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BN.MES-Cyba(mes) Congenic Rats Manifest Focal Necrosis with Eosinophilic Infiltration in the Liver without Blood Eosinophilia
http://hdl.handle.net/10091/13265
http://hdl.handle.net/10091/132654cc56654-b8e4-4d53-8190-e669f655dcf9
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-10-11 | |||||
タイトル | ||||||
タイトル | BN.MES-Cyba(mes) Congenic Rats Manifest Focal Necrosis with Eosinophilic Infiltration in the Liver without Blood Eosinophilia | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
関連識別子 | https://doi.org/10.1538/expanim.59.469 | |||||
関連名称 | 10.1538/expanim.59.469 | |||||
キーワード | ||||||
主題 | congenic rat, Cyba, eosinophilia, necrosis, polymorphism | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tomozawa, Hiroshi
× Tomozawa, Hiroshi× Nishio, Ayako× Okuhara, Yuji× Higuchi, Keiichi× Matsumoto, Kiyoshi× Mori, Masayuki |
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信州大学研究者総覧へのリンク | ||||||
表示名 | Higuchi, Keiichi | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html | |||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Matsumoto, Kiyoshi | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yVSNupkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Mori, Masayuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html | |||||
出版者 | ||||||
出版者 | Japanese Association for Laboratory Animal Science | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | EXPERIMENTAL ANIMALS. 59(4):469-478 (2010) | |||||
書誌情報 |
EXPERIMENTAL ANIMALS 巻 59, 号 4, p. 469-478, 発行日 2010-07 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The Matsumoto Eosinophilia Shinshu (MES) rat strain develops hereditary blood eosinophilia and eosinophil-related inflammatory lesions in organs due to the mutant Cyba(mes) gene. We hypothesized that a new eosinophilia model with a different phenotype could be established by changing the genetic background of rats. We bred and characterized a congenic strain, in which the mutant Cybames gene was introduced into the background of a BN strain (BN.MES-Cyba(mes)). The congenic rats showed robust proliferation of eosinophils in the bone marrow. Nonetheless, blood eosinophil levels of the rats remained within the normal range. In addition, the rats manifested focal necrosis with eosinophilic infiltration in the liver, a phenotype rarely observed in the original MES rat strain. These results imply the presence of genetic polymorphisms between MES and BN strains which modulate the mobilization of eosinophils to the peripheral circulation and organs. The newly established BN.MES-Cyba(mes) congenic rat strain, together with the original MES strain, will provide useful models for elucidating the molecular genetic mechanisms involved in the development and trafficking of eosinophils. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1341-1357 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11032321 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20660993 | |||||
関連名称 | 20660993 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2010 Japanese Association for Laboratory Animal Science | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000280173100008 |