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Association of Serum Cytokine Levels With Treatment Response to Pegylated Interferon and Ribavirin Therapy in Genotype 1 Chronic Hepatitis C Patients
http://hdl.handle.net/10091/16245
http://hdl.handle.net/10091/16245128a8c6e-cd6b-4d29-9f91-597949ef4399
名前 / ファイル | ライセンス | アクション |
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Association_Serum_Cytokine_Levels_Treatment_Response_Pegylated_Interferon.pdf (253.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-02-13 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Association of Serum Cytokine Levels With Treatment Response to Pegylated Interferon and Ribavirin Therapy in Genotype 1 Chronic Hepatitis C Patients | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1093/infdis/jiq165 | |||||
関連名称 | 10.1093/infdis/jiq165 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yoneda, Suguru
× Yoneda, Suguru× Umemura, Takeji× Katsuyama, Yoshihiko× Kamijo, Atsushi× Joshita, Satoru× Komatsu, Michiharu× Ichijo, Tetsuya× Matsumoto, Akihiro× Yoshizawa, Kaname× Ota, Masao× Tanaka, Eiji |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Umemura, Takeji | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Joshita, Satoru | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ota, Masao | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Tanaka, Eiji | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
出版者 | ||||||
出版者 | OXFORD UNIV PRESS INC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF INFECTIOUS DISEASES. 203(8):1087-1095 (2011) | |||||
書誌情報 |
JOURNAL OF INFECTIOUS DISEASES 巻 203, 号 8, p. 1087-1095, 発行日 2011-04-15 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods. We quantified a total of 8 serum cytokines before, during, and after treatment in 79 genotype 1 chronic HCV patients. Viral ISDR and core region variants were determined by direct sequencing. Results. High levels of interleukin (IL)-12 and IL-18 and more than 2 mutations in the ISDR were associated with a sustained virological response (SVR). Conversely, high baseline IL-10 levels and glutamine at amino acid 70 of the HCV core protein (Gln70) were significantly associated with a nonresponse to treatment, and patients with Gln70 had significantly higher IL-10 levels. In multivariate analysis, low IL-10, high IL-12, and high IL-18 levels were independently associated with an SVR. These 3 cytokine levels were decreased from baseline levels 4 weeks into treatment and remained low in patients with an SVR. Conclusion. Serum IL-10, IL-12, and IL-18 levels are predictive of the response to HCV treatment with pegylated interferon and ribavirin and are associated with amino acid substitutions in the ISDR and core region. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0022-1899 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA0070010X | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21398397 | |||||
関連名称 | 21398397 | |||||
権利 | ||||||
権利情報 | Copyright© The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. | |||||
権利 | ||||||
権利情報 | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in J Infect Dis. following peer review. The definitive publisher-authenticated version J Infect Dis. (2011) 203 (8): 1087-1095 is available online at: doi: 10.1093/infdis/jiq165 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000289168500008 |