WEKO3
-
RootNode
アイテム
Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy
http://hdl.handle.net/10091/17584
http://hdl.handle.net/10091/175849446d28e-6a7b-4e8f-b4dc-c95e0d90abb2
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-06-10 | |||||
タイトル | ||||||
タイトル | Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
関連識別子 | https://doi.org/10.1038/srep00180 | |||||
関連名称 | 10.1038/srep00180 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hayashi, Takuma
× Hayashi, Takuma× Horiuchi, Akiko× Sano, Kenji× Hiraoka, Nobuyoshi× Kasai, Mari× Ichimura, Tomoyuki× Sudo, Tamotsu× Tagawa, Yoh-ichi× Nishimura, Ryuichiro× Ishiko, Osamu× Kanai, Yae× Yaegashi, Nobuo× Aburatani, Hiroyuki× Shiozawa, Tanri× Konishi, Ikuo |
|||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Shiozawa, Tanri | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jmyCupkh.html | |||||
出版者 | ||||||
出版者 | NATURE PUBLISHING GROUP | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | SCIENTIFIC REPORTS. 1:180 (2011) | |||||
書誌情報 |
SCIENTIFIC REPORTS 巻 1, p. 180, 発行日 2011-12-05 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates of recurrence and metastasis. We earlier reported that mice with a homozygous deficiency for LMP2, an interferon (IFN)-gamma-inducible factor, spontaneously develop uterine LMS. The IFN-gamma pathway is important for control of tumor growth and invasion and has been implicated in several cancers. In this study, experiments with human and mouse uterine tissues revealed a defective LMP2 expression in human uterine LMS that was traced to the IFN-gamma pathway and the specific effect of JAK-1 somatic mutations on the LMP2 transcriptional activation. Furthermore, analysis of a human uterine LMS cell line clarified the biological significance of LMP2 in malignant myometrium transformation and cell cycle, thus implicating LMP2 as an anti-tumorigenic candidate. This role of LMP2 as a tumor suppressor may lead to new therapeutic targets in human uterine LMS. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2045-2322 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22355695 | |||||
関連名称 | 22355695 | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000300562400001 |