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This locus has recently been implicated in playing an important role in the pathogenesis of experimental myopia. We investigated the association of disruptions of COL1A1 gene with high myopia by analyzing the frequency of ten SNPs in a Japanese population of 330 subjects with high myopia of -9.25 D or less and 330 randomized controls without high myopia. Two SNPs (rs2075555 and rs2269336) were significantly associated with high myopia (P \u003c 0.05, Pc \u003c 0.1). Two different haplotype blocks in COL1A1 were observed by the pair-wise linkage disequilibrium between the SNPs. The frequency of GGC/GGC diplotype constructed by the three SNPs (rs2075555, rs2269336, rs1107946) was significantly high (OR = 1.6) and associated with high myopia (P = 0.028, Pc \u003c 0.084). 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The COL1A1 gene and high myopia susceptibility in Japanese
http://hdl.handle.net/10091/762
http://hdl.handle.net/10091/76240bf1dd1-9525-4333-95da-06094bb74f96
名前 / ファイル | ライセンス | アクション |
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COL1A1 Human Genetics.pdf (324.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-12-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The COL1A1 gene and high myopia susceptibility in Japanese | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00439-007-0388-1 | |||||
関連名称 | 10.1007/s00439-007-0388-1 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Inamori, Y
× Inamori, Y× Ota, M× Inoko, H× Okada, E× Nishizaki, R× Shiota, T× Mok, J× Oka, A× Ohno, S× Mizuki, N |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Ota, M | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||
出版者 | ||||||
出版者 | SPRINGER | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | HUMAN GENETICS. 122(1-2): 151-157 (2007) | |||||
書誌情報 |
Human genetics 巻 122, 号 1-2, p. 151-157, 発行日 2007-09 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The original publication is available at www.springerlink.com. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0340-6717 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA0066617X | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000250236600004 |