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Effects of activation of central nervous histamine receptors in cardiovascular regulation; studies in H1 and H2 receptor gene knockout mice
http://hdl.handle.net/10097/6432
http://hdl.handle.net/10097/643277c14ce7-01ff-4812-9ac8-f9781c4309b5
名前 / ファイル | ライセンス | アクション |
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Naunyn-Schmiedeberg05.pdf (198.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2006-12-14 | |||||
タイトル | ||||||
タイトル | Effects of activation of central nervous histamine receptors in cardiovascular regulation; studies in H1 and H2 receptor gene knockout mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Suzuki, Hideaki
× Suzuki, Hideaki× Mobarakeh, Jalal Izadi× Nunoki, Kazuo× Sukegawa, Jun× Watanabe, Haruo× Kuramasu, Atsuo× Watanabe, Takeshi× Yanai, Kazuhiko× Yanagisawa, Teruyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To elucidate the central roles of histamine receptors in cardiovascular regulatory system, systolic, mean, and diastolic blood pressures (BPs) and heart rate (HR) were examined in conscious H-1 receptor gene knockout (H1KO) mice, H-2 receptor gene knockout (H2KO) mice, H-1 and H-2 receptor gene double knockout (DKO) mice, and their respective control mice by the tail-cuff system. Histamine, histamine-trifluoromethyl-toluidine derivative (HTMT, an H-1 agonist), dimaprit (an H-2 agonist), and immepip (an H-3 agonist) were intrathecally administered to these KO mice and control mice. Basal BPs and HR were not different among these three KO mice and their control or wild-type mice. Intrathecal administration of histamine significantly increased BPs and decreased HR in control mice. The increases in BPs were produced by histamine in H1KO and H2KO mice and by HTMT and dimaprit in C57BL mice. The pressor responses by HTMT and dimaprit in C57BL mice were greater than those by histamine in H1KO and H2KO mice, although the same decreases in HR were induced by histamine in C57BL and H1KO mice and by dimaprit in C57BL mice. The selective stimulation of H-3 receptors by immepip produced a consistent decrease in BPs in control mice. These results obtained with the exogenous selective agonists of three histamine receptors suggest that the pressor responses to histamine are mediated through the stimulation of both H-1 and H-2 receptors, whereas the atropine-sensitive decrease in heart rate is mainly due to H-2 receptors which activate the vagal output to the heart. | |||||
書誌情報 |
Naunyn-Schmiedeberg's archives of pharmacology 巻 371, p. 99-106, 発行日 2005 |
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DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00210-005-1031-0 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | Springer Verlag | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学術論文 | |||||
関係URI | ||||||
識別子 | http://www.springerlink.com/content/khj69tqlgvtyryp0/fulltext.pdf | http://www.springerlink.com/content/khj69tqlgvtyryp0/fulltext.pdf | |||||
識別子タイプ | URI | |||||
登録日 | ||||||
日付 | 2006-12-14 | |||||
日付タイプ | Created | |||||
公開日(投稿完了日) | ||||||
日付 | 2006-12-14 | |||||
日付タイプ | Created | |||||
発行日 | ||||||
日付 | 2006-12-14 | |||||
日付タイプ | Created | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | 198007 bytes | |||||
公開範囲 | ||||||
値 | 学外 | |||||
更新日 | ||||||
日付 | 2010-01-27 | |||||
日付タイプ | Created |