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Barrier Proteins Remodel and Modify Chromatin To Restrict Silenced Domains
http://hdl.handle.net/10098/1632
http://hdl.handle.net/10098/163285b842e3-e801-4502-8bec-2bb12931b296
名前 / ファイル | ライセンス | アクション |
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Barrier_Proteins_Remodel_and_Modify_Chromatin_To_Restrict_Silenced_Domains.pdf (4.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-03-03 | |||||
タイトル | ||||||
タイトル | Barrier Proteins Remodel and Modify Chromatin To Restrict Silenced Domains | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
OKI, Masaya
× OKI, Masaya× VALENZUELA, Lourdes× CHIBA, Tomoko× ITO, Takashi× KAMAKAKA, Rohinton T. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Transcriptionally active and inactive domains are frequently found adjacent to one another in the eukaryotic nucleus. To better understand the underlying mechanisms by which domains maintain opposing transcription patterns, we performed a systematic genomewide screen for proteins that may block the spread of silencing in yeast. This analysis identified numerous proteins with efficient silencing blocking activities, and some of these have previously been shown to be involved in chromatin dynamics. We isolated subunits of Swi/Snf, mediator, and TFIID, as well as subunits of the Sas-I, SAGA, NuA3, NuA4, Spt10p, Rad6p, and Dot1p complexes, as barrier proteins. We demonstrate that histone acetylation and chromatin remodeling occurred at the barrier and correlated with a block to the spread of silencing. Our data suggest that multiple overlapping mechanisms were involved in delimiting silenced and active domains in vivo. | |||||
書誌情報 |
Molecular and Cellular Biology 巻 24, 号 5, p. 1956-1967, 発行日 2004-03 |
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出版者 | ||||||
出版者 | American Society for Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2707306 | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | TD00007036 | |||||
著者版フラグ | ||||||
出版タイプ | AO | |||||
出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce |