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Cdh1-APC Controls Axonal Growth and Patterning in the Mammalian Brain
http://hdl.handle.net/10098/5230
http://hdl.handle.net/10098/5230c826405b-c2d2-4abe-b220-d9e001af8e12
名前 / ファイル | ライセンス | アクション |
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2004_APC_Science-1.pdf (666.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-04-25 | |||||
タイトル | ||||||
タイトル | Cdh1-APC Controls Axonal Growth and Patterning in the Mammalian Brain | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
KONISHI, Yoshiyuki
× KONISHI, Yoshiyuki× STEGMULLER, Judith× MATSUDA, Takahiko× BONNI, Shirin× BONNI, Azad |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The anaphase-promoting complex (APC) is highly expressed in postmitotic neurons, but its function in the nervous system was previously unknown.We report that the inhibition of Cdh1-APC in primary neurons specifically enhanced axonal growth.Cdh1 knockdown in cerebellar slice overlay assays and in the developing rat cerebellum in vivo revealed cell-autonomous abnormalities in layer-specific growth of granule neuron axons and parallel fiber patterning. Cdh1 RNA interference in neurons was also found to override the inhibitory influence of myelin on axonal growth.Thus, Cdh1-APC appears to play a role in regulating axonal growth and patterning in the developing brain that may also limit the growth of injured axons in the adult brain. | |||||
書誌情報 |
Science 巻 303, p. 1026-1030, 発行日 2004 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 368075 | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | TD00007016 | |||||
著者版フラグ | ||||||
出版タイプ | AO | |||||
出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce |