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Although an increase in several cytokines in the airway during RSV infection has been reported, the mechanisms involved in airway inflammation are not fully understood. The aim of this study was to investigate the immunological deviation associated with airway inflammation by measuring cytokines and chemokine in the airway during RSV infection. Methods: One hundred and ten children under three years of age with respiratory symptoms were enrolled in this study from November 2004 through January 2005. NPAs were gently aspirated and analyzed with RSV antigen, thereafter the concentrations of IL-4, IL-10, IFN-γ, and RANTES were measured using an ELISA kit. We also investigated the prognosis of each child after 1 year by reference to clinical records or by interviews and re-evaluated the cytokine and chemokine levels. Results: In subjects 70 children were RSV positive and 40 were negative. Only four children were pediatrician diagnosed asthma when NPAs were collected. The levels of IL-4, IL-10, and RANTES were significantly higher in the RSV-positive patients than RSV-negative patients with P values at 0.0362, 0.0007, and 0.0047, respectively. In contrast, there was no significant difference in the levels of IFN-γ. Furthermore, there was a significant positive correlation between IL-10 and RANTES. RANTES levels in RSV-positive patients with wheeze were higher than in patients RSV-negative with wheeze. On the other hand in patients without wheeze RANTES was no difference between RSV-positive and RSV-negative. Whatever patients had wheeze or not, the levels of IL-10 in RSV-positive were higher than in RSV-negative. 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IL-10 and RANTES are elevated in nasopharyngeal secretions of children with respiratory syncytial virus infection.
http://hdl.handle.net/10098/7572
http://hdl.handle.net/10098/75721c79eb61-7105-479e-a314-4344e98f7b47
名前 / ファイル | ライセンス | アクション |
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RSVpaper_final-100306.pdf (3.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-24 | |||||
タイトル | ||||||
タイトル | IL-10 and RANTES are elevated in nasopharyngeal secretions of children with respiratory syncytial virus infection. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Asthma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interleukin-10 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RANTES | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Respiratory syncytial virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wheeze | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
Murai, Hiroki
× Murai, Hiroki× Terada, Akihiko× Mizuno, Mihoko× Asai, Masami× Hirabayashi, Yasutaka× Shimizu, Seiki× Morishita, Takehiro× Kakita, Hiroki× Hussein, Mohamed Hammed× Ito, Tesuya× Kato, Ineko× Asai, Kiyofumi× Togari, Hajime |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Respiratory syncytial virus (RSV) infection causes asthma-like symptoms in infants and young children. Although an increase in several cytokines in the airway during RSV infection has been reported, the mechanisms involved in airway inflammation are not fully understood. The aim of this study was to investigate the immunological deviation associated with airway inflammation by measuring cytokines and chemokine in the airway during RSV infection. Methods: One hundred and ten children under three years of age with respiratory symptoms were enrolled in this study from November 2004 through January 2005. NPAs were gently aspirated and analyzed with RSV antigen, thereafter the concentrations of IL-4, IL-10, IFN-γ, and RANTES were measured using an ELISA kit. We also investigated the prognosis of each child after 1 year by reference to clinical records or by interviews and re-evaluated the cytokine and chemokine levels. Results: In subjects 70 children were RSV positive and 40 were negative. Only four children were pediatrician diagnosed asthma when NPAs were collected. The levels of IL-4, IL-10, and RANTES were significantly higher in the RSV-positive patients than RSV-negative patients with P values at 0.0362, 0.0007, and 0.0047, respectively. In contrast, there was no significant difference in the levels of IFN-γ. Furthermore, there was a significant positive correlation between IL-10 and RANTES. RANTES levels in RSV-positive patients with wheeze were higher than in patients RSV-negative with wheeze. On the other hand in patients without wheeze RANTES was no difference between RSV-positive and RSV-negative. Whatever patients had wheeze or not, the levels of IL-10 in RSV-positive were higher than in RSV-negative. Conclusions: The increased production of IL-4, IL-10, and RANTES in the airway may play an important role in the pathophysiological mechanisms of RSV infection. | |||||
書誌情報 |
Allergology International 巻 56, 号 2, p. 157-163, 発行日 2007-06 |
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書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | TD00006192 |