WEKO3
アイテム
{"_buckets": {"deposit": "6bc41cac-9f21-4771-ac48-d6ee5a3074ff"}, "_deposit": {"id": "1655", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1655"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00001655", "sets": ["454", "484"]}, "author_link": ["4822", "4823", "4824", "4825", "4826", "4827", "4828", "4829", "4831", "4832", "4833"], "control_number": "1655", "item_1627363077551": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "1200", "bibliographicPageStart": "1194", "bibliographicVolumeNumber": "29", "bibliographic_titles": [{"bibliographic_title": "Experimental Hematology"}, {"bibliographic_title": "Experimental Hematology", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective. The CD36 molecule is expressed in platelets, monocytes, erythroblasts, and other different tissues. There are 2 types of platelet CD36 deficiency; types I and II, associated with the absence and presence of CD36 on monocytes, respectively. To clarify the involvement of the erythroid lineage in CD36 deficiency, we investigated the phenotype and RNA expression of CD36. Materials and Methods. CD36 expression was examined in 296 patients with several cardiovascular diseases in our outpatient clinic. Of them, there were 12 patients with type I and 16 with type II CD36 deficiency. A bone marrow sample was examined in 5 type I and 4 type II patients. The expression of CD36 mRNA was examined in BFU-e. The sequences of RT-PCR products of the CD36 mRNA from monocytes were examined. Results. CD36 was deficient in erythroblasts from all the 5 patients with type I as expected. CD36 was present in erythroblasts from 3 of the 4 with type II, suggesting that their abnormality is restricted to platelets (type IIa). CD36 was unexpectedly absent from erythroblasts of a single type II patient (type IIb). CD36-speciflc mRNA was identified in BFU-e from each of 2 normals, 6 type I and 6 type II including type IIb. The sequences of RT-PCR products of the CD36 mRNA in a patient with type IIa and another with type IIb showed homozygous wild alleles. Conclusion. The findings provide evidence for further heterogeneity among CD36 deficient individuals, and existence of basic principle mechanism of type II, such as glycosylation abnormality.", "subitem_description_type": "Abstract"}]}, "item_5_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "4833", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "鳥羽, 健", "nameLang": "ja"}]}]}, "item_5_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_5_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://doi.org/10.1016/s0301-472x(01)00691-9", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "International Society for Experimental Hematology"}]}, "item_5_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00641088", "subitem_source_identifier_type": "NCID"}]}, "item_5_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0301-472X", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Toba, Ken", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4822", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanawa, Haruo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4823", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Kenichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4824", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fuse, Ichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4825", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masuko, Masayoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4826", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyajima, Seiichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4827", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Masuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4828", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakaue, Minori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4829", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Abo, Toru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4831", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aizawa, Yoshifusa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4832", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "24_0015.pdf", "filesize": [{"value": "404.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 404000.0, "url": {"label": "24_0015.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/1655/files/24_0015.pdf"}, "version_id": "2b850bc0-86a2-4892-b2a6-5f590bd5dbe3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "CD36 deficiency", "subitem_subject_scheme": "Other"}, {"subitem_subject": "haematopoiesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "erythroblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BFU-e", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lineage involvement", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Erythroid Involvement in CD36 Deficiency", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Erythroid Involvement in CD36 Deficiency", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["454", "484"], "permalink_uri": "http://hdl.handle.net/10191/1169", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-04-23"}, "publish_date": "2007-04-23", "publish_status": "0", "recid": "1655", "relation": {}, "relation_version_is_last": true, "title": ["Erythroid Involvement in CD36 Deficiency"], "weko_shared_id": -1}
Erythroid Involvement in CD36 Deficiency
http://hdl.handle.net/10191/1169
http://hdl.handle.net/10191/11696ebb3979-f643-47f7-8cc3-f6f3f70f48b0
名前 / ファイル | ライセンス | アクション |
---|---|---|
24_0015.pdf (404.0 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-04-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Erythroid Involvement in CD36 Deficiency | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD36 deficiency | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | haematopoiesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | erythroblast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BFU-e | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lineage involvement | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Toba, Ken
× Toba, Ken× Hanawa, Haruo× Watanabe, Kenichi× Fuse, Ichiro× Masuko, Masayoshi× Miyajima, Seiichi× Takahashi, Masuhiro× Sakaue, Minori× Abo, Toru× Aizawa, Yoshifusa |
|||||
著者別名 | ||||||
識別子 | 4833 | |||||
識別子Scheme | WEKO | |||||
姓名 | 鳥羽, 健 | |||||
言語 | ja | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective. The CD36 molecule is expressed in platelets, monocytes, erythroblasts, and other different tissues. There are 2 types of platelet CD36 deficiency; types I and II, associated with the absence and presence of CD36 on monocytes, respectively. To clarify the involvement of the erythroid lineage in CD36 deficiency, we investigated the phenotype and RNA expression of CD36. Materials and Methods. CD36 expression was examined in 296 patients with several cardiovascular diseases in our outpatient clinic. Of them, there were 12 patients with type I and 16 with type II CD36 deficiency. A bone marrow sample was examined in 5 type I and 4 type II patients. The expression of CD36 mRNA was examined in BFU-e. The sequences of RT-PCR products of the CD36 mRNA from monocytes were examined. Results. CD36 was deficient in erythroblasts from all the 5 patients with type I as expected. CD36 was present in erythroblasts from 3 of the 4 with type II, suggesting that their abnormality is restricted to platelets (type IIa). CD36 was unexpectedly absent from erythroblasts of a single type II patient (type IIb). CD36-speciflc mRNA was identified in BFU-e from each of 2 normals, 6 type I and 6 type II including type IIb. The sequences of RT-PCR products of the CD36 mRNA in a patient with type IIa and another with type IIb showed homozygous wild alleles. Conclusion. The findings provide evidence for further heterogeneity among CD36 deficient individuals, and existence of basic principle mechanism of type II, such as glycosylation abnormality. | |||||
書誌情報 |
Experimental Hematology en : Experimental Hematology 巻 29, 号 10, p. 1194-1200, 発行日 2001-10 |
|||||
出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0301-472X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00641088 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.1016/s0301-472x(01)00691-9 | |||||
権利 | ||||||
権利情報 | International Society for Experimental Hematology | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
著者版フラグ | ||||||
値 | author |