Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/27533
Twittear
Título: | Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes |
Fecha de publicación: | 2007 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Colon cancer Mouse |
Resumen: | In the evolution of colon rectal cancer (CRC) the imbalance between cell proliferation and apoptosis is considered one of the prominent causes of tumor induction and/or progression. In order to establish the role of anti apoptotic proteins in colon cancer development, we studied with immunohistochemical techniques the expression of Survivin in a mouse model of colon carcinogenesis induced by 1,2-dimethylhydrazine treatment. In this mouse model Survivin was over-expressed during tumor development, showing a distribution mimicking that described in the correspondent human malignancies. We also correlated Survivin distribution with COX-2 and ß-Catenin expression patterns. The co-localization of COX-2/ß-Catenin/Survivin in the same epithelial cells in tumor samples lends credence to possible in vivo regulatory effects of COX-2 and ß- Catenin on the intracellular Survivin levels in mouse and human colon cancer. |
Autor/es principal/es: | Mori, F. Piro, F.R. Della Rocca, C. Mesiti, G. Giampaoli, S. Silvestre, G. Lazzaro, D. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/27533 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 17 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº 1 (2007) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Survivin and Cyclooxygenase2 are coexpressed in human and mouse colon carcinoma and in terminally differentiated colonocytes.pdf | 5,94 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.