Cannabidiol, a non-intoxicating component of cannabis, suppresses nausea and vomiting in rats and shrews
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Date
2013-02-08
Authors
Rock, E.M.
Bolognini, D.
Limebeer, C.L.
Cascio, M.G.
Anavi-Goffer, S.
Fletcher, P.J.
Mechoulam, R.
Pertwee, R.G.
Parker, L.A.
Institute for Community Engaged Scholarship
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Abstract
Cannabidiol suppressed drug-induced vomiting in shrews and nausea-associated behaviours in rats. This effect was reversed, however, if the rodents were also given chemicals that blocked serotonin receptors in a part of the brainstem. Cannabidiol may help naturally produced serotonin activate these receptors more effectively.
Description
This summary is a project of the Institute for Community Engaged
Scholarship (ICES) at the University of Guelph, with project partners:
the Catalyst Centre, SPARK Program at the
University of Guelph, and Knowledge Mobilization Unit at York
University. This project is part of the Pan-Canadian Research
Impact Network. http://csahs.uoguelph.ca/pps/Clear_Research
Keywords
Cannabis, cannabidiol, nausea, vomiting, serotonin receptors, rats, shrews