Metabolites, genomics, epigenomics, exposomics and health: Focus on serum bilirubin concentrations in subjects with metabolic syndrome from a Mediterranean population
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Otros documentos de la autoría: Coltell, Oscar; Asensio, Eva Maria; Barragán-Arnal, Rocío; Sorlí, José V; Corella, Dolores
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Título
Metabolites, genomics, epigenomics, exposomics and health: Focus on serum bilirubin concentrations in subjects with metabolic syndrome from a Mediterranean populationFecha de publicación
2019-02-03Editor
Gordon Research ConferencesTipo de documento
info:eu-repo/semantics/conferenceObjectVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Although metabolomics aims at the measurement of small molecules (metabolites) in a biological sample, this knowledge requires additional information on the related genetic variants, epigenetic regulators and enviro ... [+]
Although metabolomics aims at the measurement of small molecules (metabolites) in a biological sample, this knowledge requires additional information on the related genetic variants, epigenetic regulators and environmental factors (diet, smoking, physical activity, etc.) in order to translate the knowledge into actionable therapeutic or preventive evidence for complex disease outcomes. We focused on serum bilirubin, a metabolite generated when heme oxygenase catalyzes the degradation of heme (Figure 1). This produces biliverdin, which is converted into bilirubin by biliverdinreductase. Bilirubin is further processed in hepatocytes, where unconjugated bilirubin is conjugated by uridine diphosphate-glucuronosyltransferase (UDP-GT) to a water-soluble form for excretion. For decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice. However, data from recent years show that bilirubin is a powerful antioxidant and suggest that slightly increased serum bilirubin concentrations are protective against oxidative stress-related diseases. [-]
Descripción
Pòster presentat al congrés "Understanding Human Diseases Through Metabolomics: Interactions Among the Genome, Proteome, Gut Microbiome and Nutrition", Metabolomics and Human Health, Gordon Research Conference (February ... [+]
Pòster presentat al congrés "Understanding Human Diseases Through Metabolomics: Interactions Among the Genome, Proteome, Gut Microbiome and Nutrition", Metabolomics and Human Health, Gordon Research Conference (February 3 - 8, 2019 Ventura, CA, United States) [-]
Proyecto de investigación
Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER, “A way of making Europe”) (grants CIBER 06/03, PRX17/00500, SAF2016–80532-R) and Premio Rei Jaume I (Valencia, Spain); UniversityJaume I (grants P1–1B2013–54, COGRUP/2016/06 and UJI-B2018-69); FundacióLa Marató de TV3 (grant 538/U/2016); Generalitat Valenciana (grant PROMETEO2017/017).Derechos de acceso
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