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Título: | Alternative splicing variants of proinsulin mRNA and the effects of excess proinsulin on cardiac morphogenesis |
Autor: | Martínez-Campos, Enrique CSIC ORCID; Hernández-SanMiguel, Esther CSIC ORCID; López-Sánchez, Carmen; Pablo, Flora de CSIC ; Hernández-Sánchez, Catalina | Palabras clave: | Proinsulin Insulin gene Alternative splicing Intron retention Cardiogenesis Cardiac malformation |
Fecha de publicación: | 6-jun-2013 | Editor: | Elsevier | Citación: | FEBS Letters 587 (2013) 2272–2277 | Resumen: | Alternative forms of proinsulin mRNA with differential translational capacities and unknown significance are expressed in several developing tissues and in the adult pancreas. In the chick embryo developing heart, we observed low expression of the translationally active transcript of embryonic proinsulin (Pro1B), and predominant expression of the intron 1-unspliced variant, translationally inactive. In the embryonic mouse heart, intron 1-unspliced isoform appeared after E12.5. This tight regulation is required for normal development, since overexpression of Pro1B resulted in abnormal cardiac morphogenesis in 40% of chick embryos, and was accompanied by changes in gene expression of Amhc1and Vmhc1. | Descripción: | 31 p.-5 fig.-mat.sup. | Versión del editor: | http://dx.doi.org/10.1016/j.febslet.2013.05.060 | URI: | http://hdl.handle.net/10261/101069 | DOI: | 10.1016/j.febslet.2013.05.060 | ISSN: | 0014-5793 | E-ISSN: | 1873-3468 |
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Martínez-Campos et al_2013_FEBS Letters 587(14)2272-2277.pdf | 7,34 MB | Adobe PDF | Visualizar/Abrir |
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