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| Título: | Osteoprotegerin CGA haplotype protection against cerebrovascular complications in anti-CCP negative patients with rheumatoid arthritis |
Autor: | Genre, Fernanda CSIC ORCID; López-Mejías, Raquel; García-Bermúdez, Mercedes; Castañeda, Santos; González-Juanatey, Carlos; Llorca, Javier; Corrales, Alfonso; Ubilla, Begoña; Miranda-Filloy, J. A.; Pina, Trinitario; Gómez-Vaquero, C.; Rodríguez-Rodríguez, Luis; Fernández-Gutiérrez, B.; Balsa, Alejandro; Pascual-Salcedo, Dora; López-Longo, Francisco Javier; Carreira, Patricia E.; Blanco, Ricardo; González-Álvaro, Isidoro; Martín, J.; González-Gay, M. A. | Fecha de publicación: | 2014 | Editor: | Public Library of Science | Citación: | PLoS ONE 9 (2014) | Resumen: | © 2014 Genre et al. Introduction: Rheumatoid arthritis is an inflammatory disease with high incidence of cardiovascular disease due to accelerated atherosclerosis. Osteoprotegerin (OPG) has been associated with increased risk of atherosclerotic disease in the general population. Several polymorphisms in the OPG gene with functional effects on cardiovascular disease in nonrheumatic individuals have been described. Therefore, we aimed to analyze the effect of three of these functional OPG polymorphisms on the risk of cardiovascular disease in a large and well-characterized cohort of Spanish patients with rheumatoid arthritis. | URI: | http://hdl.handle.net/10261/102984 | DOI: | 10.1371/journal.pone.0106823 | Identificadores: | doi: 10.1371/journal.pone.0106823 issn: 1932-6203 |
| Aparece en las colecciones: | (IPBLN) Artículos |
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| OsteoprotegerinCGA_pone.0106823.pdf | 291,9 kB | Adobe PDF |  Visualizar/Abrir |
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