Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/10386
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Ace2p controls the expression of genes required for cell separation in Schizosaccharomyces pombe |
Autor: | Alonso-Núñez, María Luisa CSIC; Martín-Cuadrado, Ana Belén CSIC; Rey Iglesias, Francisco del CSIC ORCID; Vázquez de Aldana, Carlos R. CSIC ORCID CVN | Fecha de publicación: | 2-feb-2005 | Editor: | American Society for Cell Biology | Citación: | Molecular Biology of the Cell 16(4): 2003-2017 (2005) | Resumen: | Schizosaccharomyces pombe cells divide by medial fission through contraction of an actomyosin ring and deposition of a multilayered division septum that must be cleaved to release the two daughter cells. Here we describe the identification of seven genes (adg1+, adg2+, adg3+, cfh4+, agn1+, eng1+, and mid2+) whose expression is induced by the transcription factor Ace2p. The expression of all of these genes varied during the cell cycle, maximum transcription being observed during septation. At least three of these proteins (Eng1p, Agn1p, and Cfh4p) localize to a ring-like structure that surrounds the septum region during cell separation. Deletion of the previously uncharacterized genes was not lethal to the cells, but produced defects or delays in cell separation to different extents. Electron microscopic observation of mutant cells indicated that the most severe defect is found in eng1Δagn1Δ cells, lacking the Eng1p endo-β-1,3-glucanase and the Agn1p endo-α-glucanase. The phenotype of this mutant closely resembled that of ace2Δ mutants, forming branched chains of cells. This suggests that these two proteins are the main activities required for cell separation to be completed. | Descripción: | 15 pages, 10 figures.-- et al. | Versión del editor: | http://dx.doi.org/10.1091/mbc.E04-06-0442 | URI: | http://hdl.handle.net/10261/10386 | DOI: | 10.1091/mbc.E04-06-0442 | ISSN: | 1059-1524 |
Aparece en las colecciones: | (IMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
80646_Ace2_MBC.pdf | 775,95 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
36
checked on 06-abr-2024
SCOPUSTM
Citations
72
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
70
checked on 23-feb-2024
Page view(s)
387
checked on 15-abr-2024
Download(s)
333
checked on 15-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.