Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/113119
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Functional eukaryotic nuclear localization signals are widespread in terminal proteins of bacteriophages |
Autor: | Redrejo-Rodríguez, Modesto CSIC ORCID ; Muñoz-Espín, D.; Holguera, Isabel CSIC; Mario, Mencía; Salas, Margarita CSIC ORCID | Fecha de publicación: | 2012 | Editor: | National Academy of Sciences (U.S.) | Citación: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109: 18482- 18487 (2012) | Resumen: | A number of prokaryotic proteins have been shown to contain nuclear localization signals (NLSs), although its biological role remains sometimes unclear. Terminal proteins (TPs) of bacteriophages prime DNA replication and become covalently linked to the genome ends. We predicted NLSs within the TPs of bacteriophages from diverse families and hosts and, indeed, the TPs of ο29, Nf, PRD1, Bam35, and Cp-1, out of seven TPs tested, were found to localize to the nucleus when expressed in mammalian cells. Detailed analysis of ο29 TP led us to identify a bona fide NLS within residues 1-37. Importantly, gene delivery into the eukaryotic nucleus is enhanced by the presence of ο29 TP attached to the 5′ DNA ends. These findings show a common feature of TPs from diverse bacteriophages targeting the eukaryotic nucleus and suggest a possible common function by facilitating the horizontal transfer of genes between prokaryotes and eukaryotes. | URI: | http://hdl.handle.net/10261/113119 | DOI: | 10.1073/pnas.1216635109 | Identificadores: | doi: 10.1073/pnas.1216635109 issn: 0027-8424 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
M_Salas_Functional.pdf | 1,06 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
24
checked on 10-abr-2024
SCOPUSTM
Citations
35
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
31
checked on 23-feb-2024
Page view(s)
252
checked on 18-abr-2024
Download(s)
186
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.