Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/124090COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | Polymorphisms in HIF-1alpha affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx |
Autor: | Hinojar-Gutiérrez, Adolfo; Quintanilla, Miguel CSIC ORCID; Cerezo, L.; Gamallo, Carlos | Fecha de publicación: | 2013 | Editor: | Springer Nature | Citación: | Clinical and Translational Oncology 15(5): 358-363 (2013) | Resumen: | [Background]: HIF-1alpha plays a key role in the development and progression of cancer. Its polymorphic variants C1772T and G1790A have been associated with greater susceptibility to cancer and increased tumor progression. [Methods]: We determined the distribution of these polymorphisms among 121 patients with glottic cancer and 154 healthy volunteers by PCR-RFLP. We also analyzed the relationship between the presence of these polymorphisms and various clinicopathologic variables. [Results]: Advanced tumors (T3-T4) were associated with the TT variant (p = 0.036), which was present in 75 % of T4 tumors (p = 0.008). Among patients with nodal metastasis (N+), 41.7 and 22 % were carrying the TT and GA variants, respectively, compared with 9.4 and 2 % of the patients with no metastasis (N0), (p = 0.006 and p = 0.032). [Conclusions]: The presence of the TT and GA variants were associated with lymph node metastasis, while the presence of the TT variant can be associated with larger tumor size. | Descripción: | et al. | URI: | http://hdl.handle.net/10261/124090 | DOI: | 10.1007/s12094-012-0930-z | Identificadores: | doi: 10.1007/s12094-012-0930-z issn: 1699-048X e-issn: 1699-3055 |
| Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
13
checked on 18-abr-2024
WEB OF SCIENCETM
Citations
15
checked on 25-feb-2024
Page view(s)
249
checked on 23-abr-2024
Download(s)
123
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.