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Título: | Age-dependent effect of every-other-day feeding and aerobic exercise in ubiquinone levels and related antioxidant activities in mice muscle |
Autor: | Rodríguez-Bies, Elisabet CSIC; Navas, Plácido CSIC ORCID; López-Lluch, Guillermo CSIC ORCID CVN | Palabras clave: | Antioxidants Coenzyme Q Muscle NQO1 Reductases |
Fecha de publicación: | 2015 | Editor: | Oxford University Press | Citación: | Journals of Gerontology A - Biological Sciences and Medical Sciences 70(1): 33-43 (2015) | Resumen: | Aging affects many biochemical, cellular, and physiological processes in the organisms. Accumulation of damage based on oxidized macromolecules is found in many age-associated diseases. Coenzyme Q (Q) is one of the main molecules involved in metabolic and antioxidant activities in cells. Q-dependent antioxidant activities are importantly involved on the protection of cell membranes against oxidation. Many studies indicate that Q decay in most of the organs during aging. In our study, no changes in Q levels were found in old animals in comparison with young animals. On the other hand, the interventions, caloric restriction based on every-other-day feeding procedure, and physical exercise were able to increase Q levels in muscle, but only in old and not in young animals. Probably, this effect prevented the increase in lipid peroxidation found in aged animals and also protein carbonylation. Further, Q-dependent antioxidant activities such as NADH-cytochrome b5 reductase and NAD(P)H-quinone oxidoreductase 1 are also modulated by both exercise and every other day feeding. Taken together, we demonstrate that exercise and dietary restriction as every-other-day procedure can regulate endogenous synthesized Q levels and Q-dependent antioxidant activities in muscle, preventing oxidative damage in aged muscle. | URI: | http://hdl.handle.net/10261/129498 | DOI: | 10.1093/gerona/glu002 | Identificadores: | doi: 10.1093/gerona/glu002 e-issn: 1758-535X issn: 1079-5006 |
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